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The fifth national tuberculosis epidemiological survey in 2010 Technical Guidance Group of the Fifth National TB Epidemiological Survey；The Office of the Fifth National TB Epidemiological Survey Journal of Tuberculosis and Lung Health    2012, 34 (8): 485-508.   Abstract （10616）      PDF（pc） （3293KB）（74063）       Knowledge map    Save This survey aims to understand the prevalence status and trend of tuberculosis (TB) in China, and evaluate the implementation of National TB Control Programme (2001—2010). Multi-stage stratified cluster proportional random sampling method was used to select the survey population. People over 15 years old in sampled survey points were administered chest X-ray, those with suspected pulmonary TB symptoms or with suspected pulmonary TB lesion shown by X-ray were performed sputum smear and culture examination. All the bacterial strain obtained were performed drug susceptibility testing of anti-TB drugs. All active TB patients detected by this survey received the socio-economic and TB knowledge awareness questionnaire. This survey has following findings. First, the prevalence of active and smear positive was 459/100 000 and 66/100 000 respectively among population over 15 years old in 2010. Secondly, the prevalence in male was higher than in female, and gradually increase by age, peaked in 75-79 years old. Thirdly, the active and smear positive prevalence of pulmonary TB were 291/100 000 and 44/100 000 in eastern part of China, 463/100 000 and 60/100 000 in the middle part, 695/100 000 and 105/100 000 in western part, 569/100 000 and 78/100 000 in rural area, 307/100 000 and 49/100 000 in cities respectively. Fourth, the multi-drug resistance TB rate was 6.8% (19/280). Fifth, the general pulblic TB knowledge awareness rate was 57.0% (720 912/1 264 905). The sixth, the annual per capital net income of TB patient household was 3292 yuan, of those 66.8% of patients lower than 60% of nationwide per capita income. In compariton with the survey in 2000, the prevalence of smear positive pulmonary TB showed a downward trend among people over 15 years old, as well as in different age group and gender. However, the prevalence in rural area was higher than in cities, and western part also significantly higher than the middle and eastern parts. These findings indicated that although the TB prevalence has dropped, the TB burden especially for the multi-drug resistant TB is still very serious. Reference | Related Articles | Metrics

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Chinese Journal of Antituberculosis    2025, 47 (S2): 212-214.   Abstract （37）      PDF（pc） （908KB）（254）       Knowledge map    Save Reference | Related Articles | Metrics

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Dose adjustment of Immunosuppressants in anti-tuberculosis regimen containing rifampins (Report of three cases) Tao JIN Journal of Tuberculosis and Lung Health    2018, 40 (9): 1007-1011.   DOI: 10.3969/j.issn.1000-6621.2018.09.020 Abstract （1121）   HTML （3）    PDF（pc） （1024KB）（1099）       Knowledge map    Save Patients who use immunosuppressants are more likely to be infected with tuberculosis than the general population. Rifampin can accelerate the metabolism of immunosuppressive agents (especially calcium phosphatase inhibitors and glucocorticoids) and decrease the serum concentration of immunosuppressants. This will course the aggravation or recurrence of the primary disease in some patients. It is suggested that the dosage of tacrolimus or ciclosporin should be adjusted to 1.5-3 times and glucocorticoid to 2 times of the original dose for keeping the effective blood concentration when the rifampicin(or rifapentine) be used for anti-tuberculosis treatment. Furthermore, the medicines mentioned above have to be adjusted to the initial measurement after going off rifampin (or rifapentine). Wuzhi tablet or wuzhi capsule as an adjuvant drug for anti-tuberculosis treatment, not only has an effect of protecting liver and ensure the efficacy and safety of standard treatment regimens including rifampicin, but also keep the plasma concentration of calcium phosphatase inhibitor and reduce the dose of immunosuppressant. Wuzhi tablet or wuzhi capsule has good economic efficiency.. Reference | Related Articles | Metrics

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Expert consensus on off-label use of drugs for non-tuberculous mycobacteria Beijing Chest Hospital, Capital Medical University, Non-tuberculous Mycobacterial Branch of the Chinese Antituberculosis Association, Editorial Board of Chinese Journal of Antituberculosis Chinese Journal of Antituberculosis    2020, 42 (8): 769-787.   DOI: 10.3969/j.issn.1000-6621.2020.08.002 Abstract （1597）   HTML （42）    PDF（pc） （1445KB）（5480）       Knowledge map    Save For the treatment of non-tuberculous mycobacterial disease drugs or no indication, or over-treatment, over-dose, etc. The Non-tuberculous Mycobacterial Branch of the Chinese Antituberculosis Association organized relevant experts on treatment drugs such as macrolides, rifamycin, aminoglycosides, fluoroquinolones, β-lactams, tetracyclines, linezolid, clofazimine, bedaquiline, trimethoprim-sulfamethoxazole and other drugs for non-tuberculous mycobacterial disease to reach a consensus, looking forward to providing guidance to clinicians. Reference | Related Articles | Metrics

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Expert consensus on the application of Mycobacterium tuberculosis infection detection technologies Tuberculosis Control Branch of Chinese Antituberculosis Association, Standardization Professional Branch of Chinese Antituberculosis Association, Elderly Tuberculosis Control Branch of Chinese Antituberculosis Association Chinese Journal of Antituberculosis    2025, 47 (7): 813-829.   DOI: 10.19982/j.issn.1000-6621.20250231 Abstract （665）   HTML （83）    PDF（pc） （1442KB）（1498）       Knowledge map    Save Mycobacterium tuberculosis infection test is an essential method for identifying latent tuberculosis infection and clinically diagnosing tuberculosis. To better guide clinical practice, this consensus was jointly organized by the Tuberculosis Control Branch, Standardization Professional Branch and Elderly Tuberculosis Control Branch of Chinese Antituberculosis Association. Based on domestic and international research progress and clinical practice experiences, and taking into account the specific situations in different scenarios, recommendations on the application of Mycobacterium tuberculosis infection detection technologies are proposed. The consensus provides a detailed introduction to the characteristics and applications of various Mycobacterium tuberculosis infection tests and offers specific suggestions for the selection and application of detection technologies in different application scenarios, such as high-risk populations, key venue populations, and clinical tuberculosis diagnosis. In addition, the application of infection test results in tuberculosis treatment efficacy evaluation is discussed. This consensus aims to provide references for professionals related to tuberculosis prevention and control, diagnosis and treatment in medical and health institutions at all levels and types, in order to help achieve the goal of “ending the TB epidemic”. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2016, 38 (07): 521-523.   Abstract （698）      PDF（pc） （1043KB）（5048）       Knowledge map    Save Related Articles | Metrics

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Clinical characteristics, diagnostic strategies, and advances in grading criteria for tubercular uveitis Lai Xiaoyu, Duan Hongfei, Chen Xunxun, Guo Huixin, Liao Qinghua, Chen Qian, Liang Dan Chinese Journal of Antituberculosis    2025, 47 (9): 1204-1211.   DOI: 10.19982/j.issn.1000-6621.20250196 Abstract （770）   HTML （49）    PDF（pc） （1030KB）（763）       Knowledge map    Save Tubercular uveitis (TBU) is a prevalent type of extrapulmonary tuberculosis, accounts for 0.2% to 32% of uveitis globally and approximately 0.7%-4% in China. Early diagnosis and standardized treatment of TBU can lead to favorable outcomes. However, due to the lack of reliable diagnostic methods, high clinical heterogeneity, and significant diagnostic delays (averaging 11 months), the actual incidence of TBU is likely underestimated. Hence, this article provides a systematic review of the clinical characteristics, classification, diagnostic criteria, and recent advances in immunological, molecular biological, and pathological diagnostic methods for TBU. By integrating evidence from recent studies, this article aims to assist tuberculosis specialists, pulmonologists, and ophthalmologists in promoting the early and standardized diagnosis of TBU. Reference | Related Articles | Metrics

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Diagnostic value of metagenomic next-generation sequencing in nontuberculous mycobacterial pulmonary disease Kong Jiao, Chen Yuanyuan, Cai Qingshan, Zhao Yafang, Yu Yihang Chinese Journal of Antituberculosis    2022, 44 (11): 1135-1140.   DOI: 10.19982/j.issn.1000-6621.20220298 Abstract （1020）   HTML （30）    PDF（pc） （864KB）（1310）       Knowledge map    Save Objective: To investigate the diagnostic value of metagenomic next-generation sequencing (mNGS) in nontuberculous mycobacterial pulmonary disease (NTM-PD). Methods: The data of 123 patients with suspected NTM-PD admitted to the Tuberculosis Diagnosis and Treatment Center of Hangzhou Chest Hospital, Zhejiang University School of Medicine from January 2020 to February 2022 were retrospectively selected. According to the diagnostic criteria, 123 suspected NTM-PD patients were finally diagnosed as NTM-PD patients (NTM-PD group; n=74) and non-NTM-PD patients (non-NTM-PD group; n=49). All the patients underwent mNGS, PCR-fluorescence probe and mycobacterial culture in alveolar lavage fluid, sputum and lung tissue simultaneously. The sensitivity and specificity of the three methods were compared. Results: Based on the final clinical diagnosis, the sensitivities of mNGS, liquid culture and PCR fluorescence probe for NTM-PD detection were 83.8% (62/74), 78.4% (58/74) and 67.6% (50/74), respectively, the specificities were 65.3% (32/49), 91.8% (45/49) and 87.8% (43/49), respectively, the consistencies in diagnosis were 76.4% (94/123), 83.7% (103/123) and 75.6% (93/123), respectively, with Kappa values of 0.524, 0.647 and 0.521, respectively. Using liquid culture results as the standard, of mNGS and PCR fluorescence probe for NTM-PD detection, the sensitivities were 87.1% (54/62) and 75.8% (47/62), and specificities were 59.0% (36/61) and 85.2% (52/61), respectively, the consistencies in diagnosis were 73.2% (90/123) and 80.5% (99/123), and the Kappa values were 0.462 and 0.587, respectively. The strains of 74 NTM-PD patients were identified by mNGS and gene chip method, and the concordance rate of two detecting methods was 63.8% (37/58) with gene chip method as the standard for strain identification. Conclusion: For the diagnosis of NTM-PD, of mNGS detection, the sensitivity is high, it can directly identify the strains; however, the specificity is low, the specificity should be focused on improving, to better serve the clinic. Table and Figures | Reference | Related Articles | Metrics

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Spatial and temporal distribution characteristics and correlation analysis of HIV/AIDS and tuberculosis in Liangshan Yi Autonomous Prefecture, Sichuan from 2013 to 2019 LI Jing, YUAN Feng-shun, LI Ting, LI Yun-kui, GAO Wen-feng, YANG Cheng-bin, HE Jin-ge, YANG Wen Chinese Journal of Antituberculosis    2021, 43 (7): 708-715.   DOI: 10.3969/j.issn.1000-6621.2021.07.012 Abstract （2258）   HTML （25）    PDF（pc） （10045KB）（815）       Knowledge map    Save Objective To compare the temporal and spatial distribution of reported cases of HIV infection and AIDS (HIV/AIDS) and tuberculosis in Liangshan Yi Autonomous Prefecture (Liangshan Prefecture) in Sichuan from 2013 to 2019, and analyze the temporal and spatial correlation of the two diseases and the hot areas of the disease, so as to provide reference for formulating prevention and control strategies. Methods Numbers of reported HIV/AIDS and tuberculosis cases between 2013 and 2019 were collected from internet-based reporting system of Chinese Center for Disease Control and Prevention. The temporal and spatial correlation of the two diseases was analyzed by simple correlation, linear regression and spatial autocorrelation. SPSS 23.0 software was used to analyze the simple correlation and linear regression, ArcGIS 10.0 software was used to analyze the global spatial autocorrelation and local spatial autocorrelation, and the dual variable spatial autocorrelation analysis was carried out using GeoDa 1.1.4 software. Results HIV/AIDS and tuberculosis patients were reported from all the 17 counties (districts) in Liangshan Prefecture. The numbers in each year were 4139, 4406, 4005, 4802, 5570, 10105 and 4694, respectively, and the increasing rates were 6.5%, -9.1%, 19.9%, 16.0%, 81.4% and -53.5%, respectively. Numbers of reported tuberculosis cases in each year were 4590, 4323, 4453, 5931, 6748, 6432 and 6893, respectively, and the increasing rates were -5.8%, 3.0%, 33.1%, 13.8%, -4.7% and 7.2%, respectively. The results of linear regression analysis showed that the correlation coefficient (rs) between numbers of reported cases of HIV/AIDS and tuberculosis in Liangshan Prefecture according to a linear distribution with the year (x). The linear regression equation was: rs=-106.602+0.53x (regression coefficient test: t=3.109, P=0.027), the goodness of fit was average (determination coefficient R 2=0.659, correction coefficient R 2=0.591). Global spatial autocorrelation analysis showed that there was a positive spatial correlation between the reported incidence of HIV/AIDS from 2013 to 2018 (Moran’sI values were 0.213, 0.194, 0.342, 0.368, 0.271 and 0.180, respectively; P values were 0.028, 0.033, 0.003, 0.002, 0.008 and 0.027, respectively); the reported incidence of tuberculosis from 2013 to 2019 had a positive spatial correlation of medium degree and above (Moran’sI values were 0.374, 0.500, 0.451, 0.347, 0.487, 0.472 and 0.532, respectively; all P<0.05). Local spatial autocorrelation analysis showed that, from 2013 to 2018, Zhaojue County, Butuo County, and Jinyang County in Liangshan Prefecture were hot spots for reported cases of HIV/AIDS. From 2013 to 2015, the hot spots for tuberculosis were mainly concentrated on Leibo County, Meigu County, and Jinyang County; Ganluo County was a hot spot from 2015 to 2017; Zhaojue County became the hot spot in 2014 and had continued to be a hot spot since 2016, and it had spread to Yuexi County. The bivariate global spatial autocorrelation analysis showed that the reported incidence of HIV/AIDS and tuberculosis were positively correlated from 2013 to 2019 (Moran’sI values were 0.312, 0.345, 0.385, 0.419, 0.388, 0.345 and 0.293, respectively; all P<0.05). Conclusion There was a strong positive correlation between HIV/AIDS and tuberculosis reported cases in the temporal and spatial distribution, which suggested that Liangshan Prefecture should pay equal attention to the two diseases in the prevention and control of these two infectious diseases, close combination were needed, the diagnosis and treatment of HIV/AIDS and tuberculosis patients should be improved, the prevention and control measures for key areas and groups should be strengthened, and the diagnosis, treatment and health care should be improved. Table and Figures | Reference | Related Articles | Metrics

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Chinese Journal of Antituberculosis    2024, 46 (S2): 480-483.   Abstract （332）      PDF（pc） （1075KB）（2227）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Journal of Antituberculosis    2025, 47 (S2): 148-151.   Abstract （69）      PDF（pc） （921KB）（165）       Knowledge map    Save Reference | Related Articles | Metrics

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Progression of preventive treatment of latent tuberculosis infection in close contacts of patients with tuberculosis Zhe-wen REN,Jun CHENG,Cai-hong XU,Hui ZHANG Journal of Tuberculosis and Lung Health    2019, 41 (9): 1021-1024.   DOI: 10.3969/j.issn.1000-6621.2019.09.020 Abstract （1185）   HTML （41）    PDF（pc） （772KB）（1127）       Knowledge map    Save Close contacts of tuberculosis patients is one of the high-risk groups for Mycobacterium tuberculosis infection and active tuberculosis. Preventive treatment of close contacts with latent infection can decrease the incidence of tuberculosis. This study discusses the current researches on preventive treatment in close contacts with latent tuberculosis infection to clarify the research progress and existing problems of preventive treatment in this group, and to provide suggestions for further researches and explorations in the future. Table and Figures | Reference | Related Articles | Metrics

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Research progress on interstitial lung disease combined with Mycobacterium tuberculosis infection Fu Keyan, Zhu Bangzheng, Ye Jian Chinese Journal of Antituberculosis    2024, 46 (7): 823-829.   DOI: 10.19982/j.issn.1000-6621.20240171 Abstract （441）   HTML （12）    PDF（pc） （782KB）（681）       Knowledge map    Save Interstitial lung disease (ILD) and pulmonary tuberculosis (TB) are two prevalent respiratory diseases that can significantly impact health. TB, caused by Mycobacterium tuberculosis, is an infectious disease imposing a severe disease burden globally. In contrast, ILD is a group of non-communicable lung diseases characterized by chronic inflammation and alveolar interstitial fibrosis, profoundly affecting patients’ quality of life and prognosis. The interstitial and fibrotic changes in the lungs can mask signs of infection, while Mycobacterium tuberculosis infection can further worsen the condition of ILD. Therefore, when TB and ILD coexist, their interaction complicates timely diagnosis and treatment, adversely affecting the disease prognosis and outcome. This review summarizes the research progress in the epidemiology, pathogenesis, diagnostic methods, high-risk factors, and treatment of ILD combined with Mycobacterium tuberculosis infection, aiming to provide references for clinical diagnosis and treatment. Reference | Related Articles | Metrics

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LIU Bin-bin, WANG Qi-qi, YU Shi-cheng, HU Yue-hua, YAO Hong-yan, SUN Jin-fang, TAN Yun-hong Journal of Tuberculosis and Lung Health    2016, 38 (8): 615-618.   Abstract （737）      PDF（pc） （925KB）（1659）       Knowledge map    Save Related Articles | Metrics

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Guidelines for the diagnosis and treatment of superficial lymph node tuberculosis with integrated traditional Chinese and Western medicine Chinese Journal of Antituberculosis    2026, 48 (4): 429-447.   DOI: 10.19982/j.issn.1000-6621.20250509 Abstract （163）   HTML （14）    PDF（pc） （1457KB）（129）       Knowledge map    Save Developing high-quality clinical guidelines is not only essential for improving the overall standard of healthcare services but also crucial for reducing medical costs and patient burden，thereby promoting rational utilization of healthcare resources. The Chinese Medical Association published Clinical Practice Guidelines：Tuberculosis and Clinical Practice Guidelines：Surgery in 2005 and 2006，respectively，which included western medical diagnosis and treatment protocols for lymph node tuberculosis. The Chinese Association of Traditional Chinese Medicine issued Guidelines for diagnosis and treatment of common surgical diseases in traditional Chinese medicine in 2012，containing traditional Chinese medicine （TCM） diagnostic and therapeutic approaches for scrofula. In 2023，the Chinese Anti-tuberculosis Association released Expert consensus on diagnosis and treatment of superficial lymph node tuberculosis，marking the first time that integrated Chinese and Western medicine content was included. However，it provided limited details on TCM syndrome differentiation and standardized external treatment techniques，making it insufficient for guiding daily clinical decision-making in specialized departments and primary-level hospitals. In recent years，emerging research evidence on the diagnosis and treatment of superficial lymph node tuberculosis have accumulated，yet evidence-based guidelines integrating Chinese and Western medicine remain lacking. Therefore，led by Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine，and jointly initiated by the Second Affiliated Hospital of Tianjin University of Chinese Medicine，the Eighth Medical Center of the People’s Liberation Army General Hospital，and the Ulcerology Committee of the Chinese Association of Integrative Medicine，a multidisciplinary team was established. Using the GRADE methodology，an evidence-based Guidelines for the diagnosis and treatment of superficial lymph node tuberculosis with integrated Chinese and Western medicine was developed. The guidelines provide principle-based recommendations for clinical practice，covering disease definition，diagnosis and staging，TCM syndrome differentiation，with highlights on the advantages of integrated therapy，and also include the diagnosis and treatment of special populations. It aims to standardize diagnostic criteria，optimize integrated treatment pathways，and improve patient outcomes. Table and Figures | Reference | Related Articles | Metrics

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An open-label randomized and multi-center clinical trial to evaluate the efficacy of Silibinin in preventing drug-induced liver injury Journal of Tuberculosis and Lung Health    2016, 38 (1): 23-31.   DOI: 10.3969/j.issn.1000-6621.2016.01.007 Abstract （1305）      PDF（pc） （1621KB）（2649）       Knowledge map    Save Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2017, 39 (6): 576-580.   Abstract （582）      PDF（pc） （1700KB）（1200）       Knowledge map    Save Related Articles | Metrics

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Chinese Journal of Antituberculosis    2024, 46 (S2): 76-77.   Abstract （136）      PDF（pc） （1017KB）（330）       Knowledge map    Save Reference | Related Articles | Metrics

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Treatment of pulmonary tuberculosis based on the theory of “three books and two systems” in the book Li Xu Yuan Jian Mu Tingting, Zhang Xuyang, Ma Yan, Cai Qiujie Chinese Journal of Antituberculosis    2025, 47 (11): 1522-1527.   DOI: 10.19982/j.issn.1000-6621.20250329 Abstract （159）   HTML （3）    PDF（pc） （865KB）（224）       Knowledge map    Save Pulmonary tuberculosis is an important branch of Traditional Chinese Medicine(TCM) deficiency and fatigue disease, caused by invasion of pulmonary tuberculosis insects and deficiency of vital energy, involving dysfunction of lungs, spleen, and kidneys. The “three books and two systems” theory proposed by Ming Dynasty physician Wang Qishi in his book Li Xu Yuan Jian provides guidance for the diagnosis and treatment of pulmonary tuberculosis based on syndrome differentiation. This article combines ancient literature and modern clinical practice to explore the guiding significance of the “three books and two systems” theory for pulmonary tuberculosis treatment, and clarifies that Yin deficiency and fire excess are the core pathogenesis of pulmonary tuberculosis; The imbalance of lungs is the starting point, the imbalance of spleen is the basis and outcome, and the imbalance of kidneys is the root cause. The three organs interact with each other and together constitute the pathogenesis and transmission process of pulmonary tuberculosis; Treatment should be based on nourishing lungs, spleen, and kidneys, mainly by nourishing Yin and lowering fire to promote the generation of gold and water, nourishing Qi and cultivating Yin to nourish soil and produce gold, nourishing Yin and supplementing Yang to strengthen the foundation and nourish the essence. At the same time, treatment should clear fire, kill insects, and eliminate evil, while also stop bleeding and resolving phlegm, and regulate the balance of supporting the body and eliminating evil, and combine with applying test cases of taking the “three books and two systems” theory on treating pulmonary tuberculosis, in order to provide theoretical basis and clinical reference for treating pulmonary tuberculosis with TCM. Reference | Related Articles | Metrics

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Treatment and care of pulmonary tuberculosis with diabetes mellitus KANG Ying-ying, CHENG Zhi-feng Journal of Tuberculosis and Lung Health    2017, 39 (12): 1273-1277.   DOI: 10.3969/j.issn.1000-6621.2017.12.004 Abstract （1167）      PDF（pc） （1198KB）（1080）       Knowledge map    Save Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are common chronic diseases that ser-iously endanger human life and health. Diabetes is an independent risk factor for tuberculosis, while tuberculosis can increase the metabolic disorders of diabetic patients, and easily lead to a variety of acute and chronic complications of diabetes. The coexistence of the two has become a major clinical problem, bringing new challenges and problems to the disease diagnosis and treatment. Therefore, we should further understand diabetes and tuberculosis and the relationship of the two in order to achieve better effectiveness in the treatment, and improve the cure rate of tuberculosis with diabetes. Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2010, 32 (1): 52-55.   Abstract （2219）      PDF（pc） （289KB）（2794）       Knowledge map    Save Reference | Related Articles | Metrics

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Progress in interventions to improve treatment adherence among patients with pulmonary tuberculosis Meng Qiuyue, Rong Ningning, Liu Yadong, Yang Haixia, Ma Mingli Chinese Journal of Antituberculosis    2026, 48 (3): 413-418.   DOI: 10.19982/j.issn.1000-6621.20250377 Abstract （113）   HTML （16）    PDF（pc） （702KB）（169）       Knowledge map    Save Pulmonary tuberculosis (PTB) is a chronic respiratory infectious disease that continues to pose a substantial threat to global public health, characterized by a protracted disease course, high recurrence rate, and considerable treatment costs. Pharmacotherapy currently represents the primary therapeutic modality. However, due to a complex interplay of individual, socioeconomic, and contextual factors, patients generally demonstrate poor medication adherence, which consequently impairs the success rate of anti-tuberculosis treatment. This review synthesizes the major current intervention measures for improving medication adherence among PTB patients, aiming to provide a reference for the management of treatment adherence enhancement in this patient cohort. Table and Figures | Reference | Related Articles | Metrics

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Expert consensus on the diagnosis and treatment of Brucella spondylitis The Joint Tuberculosis Professional Branch of Chinese Antituberculosis Association, The Western China Bone Tuberculosis Union, The North China Union of Bone Tuberculosis Chinese Journal of Antituberculosis    2022, 44 (6): 531-538.   DOI: 10.19982/j.issn.1000-6621.20220138 Abstract （1350）   HTML （56）    PDF（pc） （1185KB）（2314）       Knowledge map    Save Brucellosis spondylitis has been increasing in recent years, because of the low early diagnosis rate, there is often the possibility of misdiagnosis and mistreatment, resulting in the difficulty of later treatment and disability of patients. In order to standardize the diagnosis and treatment process of patients with Brucella spondylitis, help more specialist to get the treatment details of such disease, and have evidence in the treatment, the Expert consensus on the diagnosis and treatment of Brucella spondylitis was jointly formulated by the Joint Tuberculosis Professional Branch of Chinese Antituberculosis Association, the Western China Bone Tuberculosis Union, the North China Union of Bone Tuberculosis. This consensus starts from the epidemiological characteristics of Brucella spondylitis, deeply expounds and discusses its common clinical manifestations, laboratory examination and diagnostic criteria, therapeutic drugs, surgical treatment methods, prognosis and so on. Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2016, 38 (07): 592-596.   Abstract （423）      PDF（pc） （660KB）（1101）       Knowledge map    Save Related Articles | Metrics

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Discussion on the clinical characteristics of skin rash caused by the anti-tuberculosis drugs and its indicators to stop using the drugs Du Debing,Luo Xiaoling,Li Meiqiong Journal of Tuberculosis and Lung Health    2007, 29 (3): 241-243.   Abstract （1981）      PDF（pc） （1747KB）（1266）       Knowledge map    Save Objective To study the clinical characteristics of skin rash caused by the anti-tuberculosis(TB) drugs and its indicators to stop using the drugs. Methods 296 TB patients with skin rash caused by anti-TB drugs out of the 3 082 hospitalized TB patients admitted during 1998 and 2005 were analyzed. Results The total rate of metamorphic reaction was 10.3%.The rate of skin rash was 9.6%(296 cases),among whom 88 were pure skin rash accounting for 2.9%,208 were the skin rash with one or more other systemetical symptomes,accounting for 6.7%;22 were without skin rash,accounting for 0.7%.The total rate of stopping the use of the drug was 61.5%. Conclusion Most of the allergic reactions caused by anti-TB drugs were systematic.With anti-allergy treatment,most patients with pure skin rash can continue the previous treatment,while the patients with other symptoms such as obvious abnormal liver function,arrhythmia,joint pain and allergic shock must stop using the anti-TB drugs immediately,and avoid using the drugs any more. Reference | Related Articles | Metrics

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Clinical practice guidelines for early detection of pulmonary tuberculosis in general medical facilities National Center of Medical Quality Control for Respiratory Diseases , Tuberculosis Branch of Chinese Medical Association , Tuberculosis Control Branch of Chinese Antituberculosis Association , China-Japan Friendship Hospital Chinese Journal of Antituberculosis    2024, 46 (2): 127-140.   DOI: 10.19982/j.issn.1000-6621.20230428 Abstract （1772）   HTML （116）    PDF（pc） （3712KB）（1603）       Knowledge map    Save The diagnosis delay of pulmonary tuberculosis not only results in aggravation and treatment challenges for patients but also leads to the continuously group spreading of tuberculosis. Early detection in general medical facilities, the main primary diagnosis healthcare contact for pulmonary tuberculosis patients, plays a crucial role in achieving the goal of “End tuberculosis strategy”. The National Center of Medical Quality Control for Respiratory Diseases, Tuberculosis Branch of Chinese Medical Association, Tuberculosis Control Branch of Chinese Antituberculosis Association, and China-Japan Friendship Hospital jointly organized experts to formulate the Clinical practice guidelines for early detection of pulmonary tuberculosis in general medical facilities based on the results of China’s tuberculosis prevention practice and the relevant guidelines of the World Health Organization and supplement relevant research evidence at home and abroad. This guide systematically summarizes the characteristics of different diagnostic techniques for pulmonary tuberculosis and proposes tuberculosis screening strategies for different target populations seeking treatment in comprehensive medical institutions, providing evidence for improving and optimizing early detection of pulmonary tuberculosis in national and regional comprehensive medical institutions. Table and Figures | Reference | Related Articles | Metrics

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To construct a risk prediction model for adult chronic kidney disease complicated with active tuberculosis based on logistic regression, decision tree, and neural network Chen Depan, Li Xiang, Zhang Kaiyi, Li Min, Xia Jiawei, Gao ChuYi, Yang Yatao, Zhang Le Chinese Journal of Antituberculosis    2026, 48 (1): 94-105.   DOI: 10.19982/j.issn.1000-6621.20250311 Abstract （92）   HTML （7）    PDF（pc） （5398KB）（178）       Knowledge map    Save Objective: To evaluate the application value of logistic regression model, decision tree model, and neural network model in predicting active tuberculosis among patients with chronic kidney disease (CKD). Methods: A retrospective analysis was conducted on 392 CKD patients admitted to the Third People’s Hospital of Kunming between January 2021 and January 2024. Among them, 266 patients with active tuberculosis were included in the observation group, and 126 patients without active tuberculosis were included in the control group. Clinical data and laboratory indicators were collected for both groups. Logistic regression, decision tree and neural network models were used to identify influencing factors and construct the risk prediction models. The model performance was compared using receiver operating characteristic (ROC) curve. Results: The area under the curve (AUC) of the logistic regression model was 0.726 (95%CI: 0.766-0.777), with a sensitivity of 45.1% and a specificity of 92.1%. Alcohol consumption, hemoptysis, low lymphocyte count, low hematocrit, high uric acid, high fibrinogen degradation products, and low IL-10 level were identified as independent predictors (all P values <0.05). The AUC of the decision tree model was 0.825 (95%CI: 0.783-0.868), with a sensitivity of 62.0% and a specificity of 82.5%. Fibrinogen degradation products served as the primary stratification variable, and further included variables such as CD4+ T lymphocytes, lymphocyte count, hematocrit, loss of appetite, and uric acid to construct a decision path. The neural network model demonstrated the best predictive performance, with an AUC of 0.876 (95%CI: 0.843-0.909), a sensitivity of 60.9%, and a specificity of 98.4%. Feature importance analysis indicated that IL-10, hematocrit, fibrinogen degradation products, and CD4+ T lymphocytes were the top four predictors. Conclusion: The neural network model exhibited the best predictive ability for detecting CKD patients with active tuberculosis. Key predictors identified in this study—such as low lymphocyte count, low CD4+ T lymphocyte count, and high fibrinogen degradation product—may help define the key population for screening. The three models provide complementary strenghths and may be applied synergistically applied in clinical practice. Enhanced tuberculosis screening is warrented for CKD patients with immunosuppression (e.g., low lymphocyte count, CD4+ T lymphocyte count), activation of coagulation and fibrinolysis (e.g., increased fibrinogen degradation products), or hemoptysis. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2016, 38 (11): 908-912.   Abstract （297）      PDF（pc） （1325KB）（988）       Knowledge map    Save Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2019, 41 (7): 799-802.   DOI: 10.3969/j.issn.1000-6621.2019.07.019 Abstract （462）   HTML （16）    PDF（pc） （753KB）（898）       Knowledge map    Save Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2013, 35 (4): 290-292.   Abstract （1206）      PDF（pc） （545KB）（104657）       Knowledge map    Save Related Articles | Metrics

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The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis Chen Liyao, Peng Xiao, Liu Yuanyuan, Shi Jin, Guo Yongli, Lu Jie Chinese Journal of Antituberculosis    2025, 47 (9): 1227-1232.   DOI: 10.19982/j.issn.1000-6621.20250143 Abstract （292）   HTML （10）    PDF（pc） （951KB）（904）       Knowledge map    Save Ferroptosis is a novel form of cell death induced by iron-dependent lipid peroxidation, closely associated with macrophage death and host-pathogen interactions, playing a significant role in tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB). This review systematically described the definition and core characteristics of ferroptosis and conducted an in-depth analysis of its molecular regulatory mechanisms, and the key signaling pathways. Furthermore, it outlined the regulatory mechanisms of ferroptosis associated with MTB-host interactions, systematically summarized ferroptosis-related biomarkers for TB diagnosis and treatment, and explored the potential applications of targeting ferroptosis in TB therapeutic. This study offers new perspectives for understanding TB pathogenesis and provides an important theoretical foundation and innovative insights for developing precision-based diagnostic and therapeutic strategies targeting ferroptosis regulation. Reference | Related Articles | Metrics

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Survey of Mycobacterium tuberculosis infection rate and analysis of associated factors among three priority populations in Yingde’s zero-TB community pilot areas，Guangdong Province Wang Yongbing, Zhong Yuexiang, Fu Xiuying, Zhang Ying, Weng Wenpei, Zhou Fangjing, Yang Yingzhou, Luo Jilun Chinese Journal of Antituberculosis    2026, 48 (4): 468-476.   DOI: 10.19982/j.issn.1000-6621.20250444 Abstract （75）   HTML （13）    PDF（pc） （786KB）（109）       Knowledge map    Save Objective：To investigate the prevalence of Mycobacterium tuberculosis （MTB） infection and its associated factors among key populations screened with the recombinant Mycobacterium tuberculosis fusion protein （EC） assay in Yingde’s zero-TB community pilot areas. This study aimed to provide data support and a scientific basis for optimizing the national zero-TB community screening strategy. Methods：The study included close contacts of active pulmonary tuberculosis patients，diabetic patients，and self-presenting respiratory disease patients who underwent EC-based screening in two pilot townships （Wangbu，Shihuipu） of Yingde City in 2023. The study analyzed the EC screening coverage，MTB infection prevalence，and employed multivariable binary logistic regression to identify factors associated with MTB infection in each subgroup. Results：A total of 1524 key individuals were screened，with a screening rate of 87.44% （1524/1743）. Among them，142 tested positive，resulting in an infection rate of 9.32% （142/1524）. The screening rate among close contacts was 88.43% （757/856） with an infection rate of 10.30% （78/757）；for diabetic patients，the rates were 82.97% （570/687） and 8.42% （48/570），respectively；and for self-presenting respiratory disease patients，the rates were 98.73% （233/236） and 9.87% （23/233）. Multivariable logistic regression analysis indicated that among household contacts of tuberculosis patients，close contact with bacteriologically confirmed patients （OR=1.972，95%CI：1.178-3.301） and self-reported smoking history （OR=2.047，95%CI：1.012-4.140） were associated with MTB infection. Among respiratory disease patients seeking medical care，male sex was associated with MTB infection （OR=2.740，95%CI：1.088-6.903）. Conclusion：The EC test demonstrated feasibility for investigating tuberculosis infection rates. Populations requiring focused attention include close contacts of etiologically positive index cases，close contacts with a smoking history，and male self-presenting patients with respiratory symptoms. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2011, 33 (2): 135-136.   Abstract （2217）      PDF（pc） （88KB）（1619）       Knowledge map    Save Reference | Related Articles | Metrics

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Analysis of syndrome differentiation and treatment for “Scrofula” (Luoli) in Huangdi Neijing Li Bo, Dong Yumeng, Cao Yuqing, Ji Xinyu, Mu Tingting, Gong Mengmeng, Zhang Xuyang, Cai Qiujie, Ma Yan Chinese Journal of Antituberculosis    2025, 47 (11): 1416-1420.   DOI: 10.19982/j.issn.1000-6621.20250326 Abstract （185）   HTML （12）    PDF（pc） （1265KB）（228）       Knowledge map    Save This paper systematically reviews the discussion of on luoli (tuberculous lymphadenitis) in the Huangdi Neijing (Neijing), revealing its core pathogenesis as “Obstruction of Shaoyang Meridians and Intermingling of Phlegm and Blood Stasis”, the disease onset perspective of “Disharmony of Zang-Fu Organs as the Root Cause and Retention of Toxic Qi in Meridians as the Symptomatic Manifestation”, and its treatment system of “Dredging Qi and Blood, and Combining Regulation and Tonification”.By analyzing key classics such as the Lingshu (Miraculous Pivot)·Cold and Heat, Lingshu (Miraculous Pivot)·Meridians, synthesized with the commentaries of later medical practitioners, the study clarifies the guiding value of Neijing theory for modern diseases such as tuberculous lymphadenitis and autoimmune lymphadenopathy, providing classical support for clinical practice. Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2014, 36 (1): 67-69.   DOI: 10.3969/j.issn.1000-6621.2014.01.015 Abstract （1610）      PDF（pc） （741KB）（1137）       Knowledge map    Save Reference | Related Articles | Metrics

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Expert consensus on molecular biology diagnosis of nontuberculous mycobacteria diseases Nontuberculous Mycobacterial Diseases Branch of Chinese Antituberculosis Association Chinese Journal of Antituberculosis    2025, 47 (8): 961-975.   DOI: 10.19982/j.issn.1000-6621.20250225 Abstract （617）   HTML （33）    PDF（pc） （1412KB）（1693）       Knowledge map    Save The incidence of nontuberculous mycobacteria (NTM) disease has been on the rise. Traditional methods such as acid-fast bacilli staining and mycobacterial culture suffer from limitations including low sensitivity, being time-consuming, and inability to identify specific species. In contrast, molecular biology detection technologies have demonstrated unique advantages and great application prospects in the diagnosis of NTM diseases and precise species identification. However, there is lack of systematic and comprehensive guideline for the molecular diagnosis of NTM disease in China. In order to standardize the clinical application of molecular diagnostic techniques for NTM diseases and enhance the diagnosis and treatment capabilities of medical professionals, the Nontuberculous Mycobacterial Diseases Branch of Chinese Antituberculosis Association organized a writing group composed of domestic experts in the fields of NTM diseases, infectious diseases, microbiology, and methodology. Through systematic literature reviews, multiple rounds of online and offline discussions, and questionnaire surveys, the group evaluated the respective merits, limitations, and implementation status of current molecular detection technologies, discussed key issues in molecular diagnosis of NTM diseases, and ultimately formulated this consensus after iterative revisions through multiple consensus conferences. Focusing on core issues such as molecular targets for NTM disease diagnosis, molecular biological diagnostic techniques, and standardized interpretation protocols, the consensus formulated 11 evidence-based recommendations. It systematically establishes a technical framework and clinical application pathway for molecular biological diagnosis of NTM diseases, addressing core challenges like technical fragmentation and inconsistent interpretation standards. It provides actionable guidance for clinicians, clinical laboratories, and public health departments. Table and Figures | Reference | Related Articles | Metrics

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Expert consensus on nutritional assessment and nutritional support treatment for patients with severe tuberculosis CHEN Zhi, LIANG Jian-qin Chinese Journal of Antituberculosis    2022, 44 (5): 421-432.   DOI: 10.19982/j.issn.1000-6621.20220041 Abstract （1194）   HTML （59）    PDF（pc） （1328KB）（2484）       Knowledge map    Save There is a two-way relationship between tuberculosis and nutritional status, they are related to each other. Tuberculosis can lead to the occurrence of nutritional risk, and is easy to develop nutritional related diseases, such as lack of nutrition, low immune function, electrolyte imbalance and so on. And poor nutritional status can lead to lymphocytic reduction, low cellular immunity and susceptibility to tuberculosis and other infectious diseases. Malnutrition is an independent risk factor affecting the prognosis and mortality of adult patients with severe tuberculosis. However, the relevant guidance documents on nutritional assessment and nutritional support treatment for patients with severe tuberculosis is still lacking. Therefore, combined with the experience and methods of nutritional support therapy in China and the latest guidelines for enteral and parenteral nutrition in the United States and Europe, the Eighth Medical Center of Chinese PLA General Hospital and the Editorial Board of Chinese Journal of Antituberculosis jointly organized experts to draw up Expert consensus on nutrition assessment and nutritional support treatment for patients with severe tuberculosis, in order to get standardized individual nutritional assessment and nutritional support treatment for patients with severe tuberculosis, and improve the prognosis and reduce mortality. This consensus expounds the importance of nutritional assessment and nutritional support treatment for patients with severe tuberculosis, the types of commonly used nutritional agents, and gives recommendations on the principles and standards of nutritional assessment and nutritional support treatment, the types and ways of giving nutrition, the types of severe tuberculosis, the complications and the nutritional support for special populations. Table and Figures | Reference | Related Articles | Metrics

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Analysis of the clinical characteristics of post-tuberculosis bronchiectasis Han Yanzhuo, Lu Zhenhui, Su Ben, Zhou Rui, Chen Jiajun, Wu Xianwei, Wu Dingzhong, Zhang Shaoyan, Qiu Lei Chinese Journal of Antituberculosis    2026, 48 (4): 510-517.   DOI: 10.19982/j.issn.1000-6621.20250418 Abstract （74）   HTML （5）    PDF（pc） （782KB）（103）       Knowledge map    Save Objective：To investigate the clinical characteristics of post-tuberculosis bronchiectasis （PTBE） to provide a basis for individualized diagnosis and treatment. Methods：A cross-sectional study was conducted. A total of 350 patients with stable bronchiectasis from Longhua Hospital Affilicated to Shanghai University of Traditional Chinese Medicine between July 2021 and December 2024 were enrolled. According to the history of pulmonary tuberculosis，patients were divided into a post-tuberculosis bronchiectasis group （PTBE group，n=86） and a non-post-tuberculosis bronchiectasis group （NPTBE group，n=264）.Demographic characteristics，acute exacerbations，pulmonary function，chest CT findings，colonization with pseudomonas aeruginosa，clinical symptoms and related scores，blood routine tests，albumin levels，and lymphocyte subsets were compared between the two groups. Results：The median disease duration in the PTBE group was 20.00 （15.00，23.00） years，significantly longer than the 11.00 （6.75，15.00） years in the NPTBE group （Z=-9.554，P<0.001）. The proportion of patients with ≥3 acute exacerbations within one year was 48.84% （42/86） in the PTBE group，significantly higher than 18.94% （50/264） in the NPTBE group （χ2=29.926，P<0.001）. The hospitalization rate due to acute exacerbations within one year was 51.16% （55/86） in the PTBE group，significantly higher than 27.65% （73/264） in the NPTBE group （χ2=16.113，P<0.001）. The proportion of patients with involvement of ≥3 lung lobes was 84.88% （73/86） in the PTBE group，significantly higher than 55.30% （146/264） in the NPTBE group （χ2=24.237，P<0.001）. The forced vital capacity percent predicted （FVC% pred） was 0.66±0.08 in the PTBE group，significantly lower than 0.70±0.09 in the NPTBE group （t=3.968，P<0.001）. The proportion of patients with a forced expiratory volume in one second percent predicted （FEV1% pred）<70% was 48.84% （42/86） in the PTBE group，significantly higher than 27.65% （73/264） in the NPTBE group （χ2=13.197，P<0.001）. The rate of chronic Pseudomonas aeruginosa colonization was 62.79% （54/86） in the PTBE group，significantly higher than 29.17% （77/264） in the NPTBE group （χ2=31.321，P<0.001）. The incidence of hemoptysis was 18.60% （16/86） in the PTBE group，significantly higher than 6.82% （18/264） in the NPTBE group （χ2=10.275，P=0.001）. Conclusion：Patients with post-tuberculosis bronchiectasis present with a longer disease duration，more extensive pulmonary structural destruction，higher risk of chronic Pseudomonas aeruginosa colonization，and more frequent acute exacerbations. Early and intensive anti-infective therapy and pulmonary rehabilitation interventions are recommended for these patients.. Table and Figures | Reference | Related Articles | Metrics

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Risk factors of pulmonary tuberculosis incidence in Guangzhou: a paired case-control study HE Zhi-qing，HU Gui-fang，ZI Qing-lan，TANG Hui-hong，GONG Fang，CHEN Shu-zhong，LEI Yu，BAO Wan-ling，LIU Gui-si Journal of Tuberculosis and Lung Health    2012, 34 (7): 425-432.   Abstract （3639）      PDF（pc） （781KB）（1545）       Knowledge map    Save Objective  To explore the risk factors affecting the TB incidence in Guangzhou, and provide scientific basis for pulmonary tuberculosis(PTB) prevention.  Methods  This is a 1：1 matched case-control study. Two hundreds and fifty smear positive tuberculosis patients in case group and the same number of people selected from household close contacts of smear positive in control group were investigated by unified self-designed questionnaire. A total of 25 indicators were surveyed including level of education, occupation, personal monthly income, the family economic responsibility, family economic status, smoking, excessive alcohol consumption, exercise, marriage, drug abuse, history of diabetes, the housing area, room ventilation, darkness and dampness, the surrounding environmental quality and 9 psychological stress indicators. The psychological stress was investigated by Yang Desen life Event scale (LES), Jiang Qianjin Trait Coping Style Questionnaire（TCSQ），Xiao Shuiyuan social support rating scale（SSRS）. Measured by the pre-survey, the Cronbach’s coefficient of the questionnaire was 0.83. Two hundred and sixty-eight pieces of questionnaire were issued for PTB patients, and 250 valid were returned with the effective response rate of 93.3%. All these 250 patients were enrolled in the case group. 1206 pieces of questionnaire were issued for household close contacts, and 1143 valid were returned with the effective response rate of 94.8%. Among these 1143 household contacts, 250 controls were selected according to 1：1 match with cases. The matching principle is same gender, and age gap less than 3 years old. The univariate analysis is made to screen the risk factors that may affect the TB incidence, and then the multivariate conditional logistic regression model is made for analysis. Wald χ2, P values, OR values and their 95% CI is calculated for each indicator. P value ≤ 0.10 is considered statistically significant.  Results  A total of fifteen indicators are statistically significant in univariate analysis, nine enter into the multivariate analysis. Among which, six are risk factors of TB incidence. They are personal monthly income (three levels, <1000 yuan/month, 1000— yuan/month, ≥ 3000/month, Wald χ2 value is 13.492,1.379, P=0.000,0.240), bearing the primary responsibility of family income  (Wald χ2 =17.820, P=0.000), smoking (Wald χ2 =9.489, P=0.002), excessive alcohol consumption (Wald χ2=4.141, P=0.042); the total amount of stimulation of the life events (Wald χ2 =6.995, P=0.008), negative coping (Wald χ2 =14.806, P=0.000. Their OR value (95% CI values) are 4.178 (1.948—8.961), 1.475 (0.771—2.821), 6.457 (2.716—15.352), 2.960 (1.484—5.905), 5.048 (1.062—24.004), 1.030 (1.008—1.052), 1.131 (1.062—1.204) respectively. Conclusion  Low personal incomes, bearing the primary responsibility for the family income, smoking, excessive alcohol consumption, life event stimulation and negative response are the risk factors of PTB incidence in Guangzhou. Reference | Related Articles | Metrics

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Interpretation of Guideline on tuberculosis infection prevention and control in primary health care institute Cheng Jun, Lu Wei Chinese Journal of Antituberculosis    2022, 44 (8): 762-767.   DOI: 10.19982/j.issn.1000-6621.20220207 Abstract （916）   HTML （41）    PDF（pc） （1029KB）（1028）       Knowledge map    Save Guideline on tuberculosis infection prevention and control in primary health care institute (T/CHATA-018-2022), one of association standards launched by Chinese Antituberculosis Association, was put into force from Feb, 24th, 2022. In order to make the potential users to understand this standard well, the author described its background, main content and basis of measurements, and application. Reference | Related Articles | Metrics

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Expert consensus on the clinical application of nucleic acid MALDI-TOF MS technique in the diagnosis of tuberculosis and non-tuberculosis mycobacteriosis Senior Department of Tuberculosis, the th Medical Center of Chinese PLA General Hospital, Editorial Board of Chinese Journal of Antituberculosis, Tuberculosis Control Branch of China Intrnational Exchange and Promotive Association for Medical and Health Care Chinese Journal of Antituberculosis    2023, 45 (6): 543-558.   DOI: 10.19982/j.issn.1000-6621.20230113 Abstract （904）   HTML （60）    PDF（pc） （3420KB）（1533）       Knowledge map    Save Nucleic acid matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) technique has been increasingly applied in the etiology and drug resistance diagnosis of tuberculosis and non-tuberculous mycobacteriosis, providing a rapid and accurate basis for early diagnosis, differential diagnosis, and drug resistance identification. However, it needs to be normalized that the clinician’s understanding and grasp of sample selection, retention, submitting time and precautions, and interpretation of report results. This consensus summarizes the clinical indications and specimen collection precautions of nucleic acid MALDI-TOF MS detection technique for the diagnosis of tuberculosis and non-tuberculous mycobacteriosis, and introduces how to correctly interpret the reported results of nucleic acid MALDI-TOF MS technique used to mycobacterial species and drug resistance. It has important significance to further standardize the clinical application of nucleic acid MALDI-TOF MS technique in the diagnosis of tuberculosis and non-tuberculous mycobacteriosis, improve the level of clinical diagnosis, and guide the early accurate and effective clinical treatment. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2015, 37 (6): 603-606.   Abstract （216）      PDF（pc） （1102KB）（842）       Knowledge map    Save Related Articles | Metrics

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Chinese Journal of Antituberculosis    2025, 47 (S2): 127-130.   Abstract （36）      PDF（pc） （972KB）（133）       Knowledge map    Save Reference | Related Articles | Metrics

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Status and structural equation model analysis of knowledge, attitude and practice of tuberculosis prevention and control among college students in Xi’an CAO Yi,ZHANG Shao-ru,ZHANG Tian-hua,JIANG Hua-lin,REN Dan,LI Yan,REN Jing,LIU Hai-ni,HUA Zhong-qiu. Journal of Tuberculosis and Lung Health    2018, 40 (11): 1201-1207.   DOI: 10.3969/j.issn.1000-6621.2018.11.011 Abstract （1416）   HTML （21）    PDF（pc） （1062KB）（807）       Knowledge map    Save Objective To realize the current situation on knowledge, attitude and practice (KAP) of tuberculosis (TB) prevention and control among non-medical students in Xi’an, construct a structure equation model (SEM) of students’ KAP of TB control based on KAP theory to explore the interaction mechanism of basic information, history of contact and health education, knowledge, attitude and behavior, and then put forward to the suggestions and countermeasures for the practice of TB prevention and control in colleges.Methods Eight hundred and fifty-one students from 4 non-medical colleges of Xi’an selected by purposive sampling were investigated with the questionnaire of the national survey of KAP to TB control designed by the Chinese Center for Disease Control and Prevention (which includes items related knowledge, attitude, behavior of TB prevention and care), and a self-design general information questionnaire (including questions related students’ basic information and personal history) from Dec. 2016 to Mar. 2017. A total of 808 valid questionnaires were collected with an effective rate of 94.9%. Amos 21.0 was used to analyze the relationship between basic information, personal history, knowledge, attitude and behavior.Results The score of knowledge related TB prevention and care was low. About 70.8% (1715/2424) and 37.1% (600/1616) students hold a positive attitude and behavior, respectively. The KAP structural equation model fitting degree was good. Some goodness-of-fit indices were as follows: goodness of fit index=0.97, adjusted goodness of fit index=0.95, comparative fit index=0.95. The results of SEM showed that personal history, knowledge and attitude had positive effects on behavior. Knowledge had the biggest total effect of 0.74 on behavior: the direct effect coefficient was 0.69 (CR=8.38, P=0.003), and the coefficient of indirect effect of knowledge on behavior through influencing attitude was 0.05 (P=0.003). The personal history had an indirect influence behavior with the coefficients of 0.45 (P=0.001). Attitude had a minimum direct effect of 0.16 on behavior (CR=2.79, P=0.007).Conclusion Knowledge of TB prevention and care among non-medical students in Xi’an needs to be improved. Knowledge, personal history, and attitude all can affect students’ behavior of TB prevention and control, whereas the effect of attitude is limited. Therefore, comprehensive and effective interventions should be taken to improve the students’ awareness of TB, establish a correct attitude towards TB prevention and control, and make them actively learn and disseminate knowledge of prevention and control, emphasizing on the simultaneous development of KAP. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2012, 34 (2): 120-123.   Abstract （1501）      PDF（pc） （599KB）（895）       Knowledge map    Save Reference | Related Articles | Metrics

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Prevalence of latent tuberculosis infection and willingness for preventive treatment among Chinese students:A Meta-analysis and systematic review Ming Yao, Chen Minghui, Wang Fang, Hu Feifei, Wang Zhi Chinese Journal of Antituberculosis    2025, 47 (12): 1556-1565.   DOI: 10.19982/j.issn.1000-6621.20250257 Abstract （204）   HTML （18）    PDF（pc） （2238KB）（235）       Knowledge map    Save Objective: To determine the prevalence of latent tuberculosis infection (LTBI) and the willingness to accept tuberculosis preventive treatment among Chinese students through a meta-analysis. Methods: Systematic searches were conducted in databases including CNKI, Wanfang Database, VIP Database, PubMed, Embase, Cochrane Library, and Web of Science, with the search period spanning from the inception of each database to April 23, 2025. The literature consisted of publicly published Chinese and English articles. Two researchers independently screened the literature, extracted data from the included studies, and assessed the quality of the literature. Meta-analysis was performed using Stata 15.1 software. Results: A total of 44 Chinese and English articles were included. The pooled prevalence of LTBI among Chinese students was 6.7% (95%CI: 5.9%-7.5%), and the acceptance rate for TPT was 41.5% (95%CI: 27.0%-56.0%). Subgroup analyses revealed lower latent tuberculosis infection rates in the following groups: tuberculin skin test (6.3% (95%CI: 5.4%-7.1%)), North China region (3.6% (95%CI: 1.7%-5.4%)), primary school students (3.2% (95%CI:1.9%-4.5%)), studies with a sample size of ≥10000 (4.5% (95%CI: 3.4%-5.5%)), studies conducted before 2017 (6.0% (95%CI: 4.9%-7.1%)), and non-close contacts (6.1% (95%CI: 5.4%-6.8%)). In contrast, higher latent tuberculosis infection rates were observed in the following subgroups: other diagnostic criteria (including interferon-gamma release assay, T-cell spot test for tuberculosis infection, and recombinant Mycobacterium tuberculosis fusion protein skin test) (9.2% (95%CI: 6.1%-12.2%)), East China region (10.1% (95%CI: 7.8%-12.3%)), middle school students (6.6% (95%CI: 5.6%-7.7%)), studies with a sample size of <10000 (8.7% (95%CI: 7.0%-10.3%)), studies conducted after 2017 (6.8% (95%CI: 5.8%-7.7%)), and close contacts (8.3% (95%CI: 6.2%-10.3%)). Conclusion: The prevalence of LTBI among Chinese students remains relatively high, while the willingness to accept TPT is comparatively low. Table and Figures | Reference | Related Articles | Metrics

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Expert consensus on therapy and drug monitoring clinical application of anti-tuberculosis drug (updated in 2025) Pharmaceutical Professional Branch of Chinese Antituberculosis Association Chinese Journal of Antituberculosis    2026, 48 (2): 167-187.   DOI: 10.19982/j.issn.1000-6621.20250435 Abstract （269）   HTML （23）    PDF（pc） （1985KB）（280）       Knowledge map    Save Therapeutic drug monitoring (TDM) is a method to develop individualized dosing regimens for patients based on the measurement of drug exposure pharmacological biomarkers, or efficacy indicators in the body, using quantitative pharmacological models and taking the drug treatment window as the benchmark. Its core is individualized drug therapy. In order to further guide and standardize the TDM work of anti-tuberculosis drugs in Chinese medical institutions, ensuring scientific rigor, ethical practice, and standardized procedures for maximal patient benefit, Pharmaceutical Professional Branch of Chinese Antituberculosis Association, in conjunction with Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute systematically updated the indications, monitoring methods, dose adjustment, and application in special populations of TDM on the basis of the 2021 Expert consensus on clinical application of therapeutic drug monitoring for anti-tuberculosis drugs. This consensus is registered on the international practice guidelines platform, and the formulation process follows the principles of methodology. Drawing on the collaborative expertise of tuberculosis pharmaceutical and clinical experts, along with the latest evidence-based research and practical experience, this consensus will provide scientific and feasible guidance for the clinical implementation of TDM. Table and Figures | Reference | Related Articles | Metrics

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Journal of Tuberculosis and Lung Health    2019, 41 (4): 369-370.   DOI: 10.3969/j.issn.1000-6621.2019.04.001 Abstract （632）   HTML （15）    PDF（pc） （1081KB）（1085）       Knowledge map    Save Reference | Related Articles | Metrics

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Feasibility study of domestic four-drug fixed-dose combination under DOTS as initial treatment in ptients with smear positive pulmonary tuberculosis Ma Liping,Wu Xiaoguang,Chu Naihui,Zhu Lizhen,Shan Bin,Wang Min,Wang Yan,Zhang Wenshu,Li Huijun,Hou Dong Journal of Tuberculosis and Lung Health    2010, 32 (5): 21-25.   Abstract （1598）      PDF（pc） （233KB）（1393）       Knowledge map    Save Objective To assess antituberculosis efficacy and adverse events of domestic four-drug fixed-dose combination in smear positive pulmonary tuberculosis under the management of directly observed treatment short-course (DOTS).  Method Two hundreds and twenty-five new patients with smear positive pulmonary tuberculosis were randomly divided into a treatment group (2yinuonikang/4yifu capsule) and a control group (2HRZE/4HR) to observe rates of sputum negative conversion in short time, chest X-ray improvement and advert events.  Result The sputum negative conversion rates in the treatment group and the control were 94.6% and 93.8% at the 2nd month, and 99.1% and 96.5% at the end of treatment. Chest radiography showed remarkable improvement of lesions. The foci absorption rate in the treatment group and the controls were 98.2% and 97.4%, respectively, and the cavity closure rates were 72.2% in the treatment group and 56.4% in the controls. Hepatic dysfunction was seen among 4 cases in the treatment group and 3 cases in the controls.  Conclusion Domestic four-drug fixed-dose combination shows an excellent therapeutic efficacy, safety and good compliance in antituberculous chemotherapy which could be recommended widely in tuberculosis control in China. Reference | Related Articles | Metrics

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Auxiliary diagnostic value of interferon-γ inducible protein 10 in tuberculous pleural effusions REN Wei-cong, NIE Li-hui, JIANG Xiao-ying, LIU Yi，SUN Zhao-gang, ZHANG Xu-xia, TIAN Miao, CHENG Jun, ZHANG Jian-yuan, LI Chuan-you Journal of Tuberculosis and Lung Health    2013, 35 (2): 108-110.   Abstract （1831）      PDF（pc） （852KB）（759）       Knowledge map    Save Objective  To study the diagnostic value of interferon-γ inducible protein 10 (IP-10) level in tuberculous pleural fluid.  Methods  Between October 2010 and October 2011,195 patients adimitted to Beijing Chest Hospital were recruited consecutively, 112 tuberculous pleural effusions and 83 malignant pleural effusions were measured the IP-10 level by enzyme-linked immunosorbent assay（ELISA）.  Results  The IP-10 levels were significantly higher in tuberculous pleural effusions compared with malignant pleural effusions, and their difference  was significant ［196 855（4518-1 512 550） pg/ml vs. 7432（173-97 881） pg/ml, U=575.00, P<0.001］. Using a cut off value of 10 964 pg/ml estimated from IP-10 receiver operating characteristic analysis, the sensitivity, specificity and efficiency of IP-10 were 82.14%（92/112）, 93.98% (78/83)and 87.18%(170/195),respectively. Conclusion  The IP-10 level in pleural effusion is significant for the early diagnosis and differential diagnosis. Reference | Related Articles | Metrics