Auxiliary diagnostic value of interferon-γ inducible protein 10 in tuberculous pleural effusions

Chinese Journal of Antituberculosis ›› 2013, Vol. 35 ›› Issue (2): 108-110.

Auxiliary diagnostic value of interferon-γ inducible protein 10 in tuberculous pleural effusions

REN Wei-cong, NIE Li-hui, JIANG Xiao-ying, LIU Yi，SUN Zhao-gang, ZHANG Xu-xia, TIAN Miao, CHENG Jun, ZHANG Jian-yuan, LI Chuan-you

Department of Bacteriology and Immunology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Capital University of Medicine, Beijing 101149, China

Received:2012-12-19 Online:2013-02-10 Published:2013-05-13
Contact: LI Chuan-you E-mail:lichuanyou6688@hotmail.com

Abstract

Abstract: Objective To study the diagnostic value of interferon-γ inducible protein 10 (IP-10) level in tuberculous pleural fluid. Methods Between October 2010 and October 2011,195 patients adimitted to Beijing Chest Hospital were recruited consecutively, 112 tuberculous pleural effusions and 83 malignant pleural effusions were measured the IP-10 level by enzyme-linked immunosorbent assay（ELISA）. Results The IP-10 levels were significantly higher in tuberculous pleural effusions compared with malignant pleural effusions, and their difference was significant ［196 855（4518-1 512 550） pg/ml vs. 7432（173-97 881） pg/ml, U=575.00, P<0.001］. Using a cut off value of 10 964 pg/ml estimated from IP-10 receiver operating characteristic analysis, the sensitivity, specificity and efficiency of IP-10 were 82.14%（92/112）, 93.98% (78/83)and 87.18%(170/195),respectively. Conclusion The IP-10 level in pleural effusion is significant for the early diagnosis and differential diagnosis.

Key words: Tuberculosis, pleural/diagnosis, Chemokine CXCL10

REN Wei-cong, NIE Li-hui, JIANG Xiao-ying, LIU Yi，SUN Zhao-gang, ZHANG Xu-xia, TIAN Miao, CHENG Jun, ZHANG Jian-yuan, LI Chuan-you. Auxiliary diagnostic value of interferon-γ inducible protein 10 in tuberculous pleural effusions[J]. Chinese Journal of Antituberculosis, 2013, 35(2): 108-110.

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