The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis

doi:10.19982/j.issn.1000-6621.20250143

Abstract

Abstract:

Ferroptosis is a novel form of cell death induced by iron-dependent lipid peroxidation, closely associated with macrophage death and host-pathogen interactions, playing a significant role in tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB). This review systematically described the definition and core characteristics of ferroptosis and conducted an in-depth analysis of its molecular regulatory mechanisms, and the key signaling pathways. Furthermore, it outlined the regulatory mechanisms of ferroptosis associated with MTB-host interactions, systematically summarized ferroptosis-related biomarkers for TB diagnosis and treatment, and explored the potential applications of targeting ferroptosis in TB therapeutic. This study offers new perspectives for understanding TB pathogenesis and provides an important theoretical foundation and innovative insights for developing precision-based diagnostic and therapeutic strategies targeting ferroptosis regulation.

Key words: Immunity, Mycobacterium tuberculosis, Review literature as topic

CLC Number:

R52
R392.1

Chen Liyao, Peng Xiao, Liu Yuanyuan, Shi Jin, Guo Yongli, Lu Jie. The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis[J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1227-1232. doi: 10.19982/j.issn.1000-6621.20250143

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