Abstract: Objective To study the clinical characteristics of skin rash caused by the anti-tuberculosis(TB) drugs and its indicators to stop using the drugs. Methods 296 TB patients with skin rash caused by anti-TB drugs out of the 3 082 hospitalized TB patients admitted during 1998 and 2005 were analyzed. Results The total rate of metamorphic reaction was 10.3%.The rate of skin rash was 9.6%(296 cases),among whom 88 were pure skin rash accounting for 2.9%,208 were the skin rash with one or more other systemetical symptomes,accounting for 6.7%;22 were without skin rash,accounting for 0.7%.The total rate of stopping the use of the drug was 61.5%. Conclusion Most of the allergic reactions caused by anti-TB drugs were systematic.With anti-allergy treatment,most patients with pure skin rash can continue the previous treatment,while the patients with other symptoms such as obvious abnormal liver function,arrhythmia,joint pain and allergic shock must stop using the anti-TB drugs immediately,and avoid using the drugs any more.

Key words: Skin rash, Medicine, Anti-tuberculosis, Allergy