动物模型和3D细胞模型在结核病研究中的应用进展

doi:10.19982/j.issn.1000-6621.20240347

摘要/Abstract

摘要：

由结核分枝杆菌(Mycobacterium tuberculosis, MTB)引起的结核病是全球最主要的传染病之一,但目前对于MTB和宿主之间的相互作用机制知之甚少。动物模型和3D细胞模型为结核病的研究提供了更加全面和复杂的实验环境,有助于模拟疾病的多个方面。笔者对动物模型和3D细胞模型在结核病研究中的应用等方面进行综述,以期能为结核病的预防、诊断和治疗开辟新的途径。

关键词: 结核, 疾病模型,动物, 综述文献(主题)

Abstract:

Tuberculosis, caused by Mycobacterium tuberculosis (MTB), remains one of the world’s most significant infectious diseases, yet the mechanisms underlying MTB-host interactions are not fully understood. Animal models and 3D cell models offer a comprehensive and intricate experimental platform that facilitates the simulation of various aspects of tuberculosis pathophysiology. This review examines the application of these models in tuberculosis research, aiming to pave the way for advances in prevention, diagnosis, and treatment.

Key words: Tuberculosis, Disease models, animal, Review literature as topic

中图分类号:

R52
R378

黎超凡, 陈志. 动物模型和3D细胞模型在结核病研究中的应用进展[J]. 中国防痨杂志, 2024, 46(12): 1527-1534. doi: 10.19982/j.issn.1000-6621.20240347

Li Chaofan, Chen Zhi. Advances in the application of animal models and 3D cell models in tuberculosis research[J]. Chinese Journal of Antituberculosis, 2024, 46(12): 1527-1534. doi: 10.19982/j.issn.1000-6621.20240347

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