复方甘草甜素对抗结核治疗的药物性肝炎的预防效果观察

中国防痨杂志 ›› 2007, Vol. 29 ›› Issue (1): 19-21.

复方甘草甜素对抗结核治疗的药物性肝炎的预防效果观察

杨松；张耀亭；殷建团；

解放军第175医院南京军区结核病中心漳州363000；

出版日期:2007-01-10 发布日期:2007-11-03
基金资助:
福建省青年科技人才创新项目资金资助(2005J081)

Preventive effect of glycyrrhizin on the hepatitis resulted from antituberculous drugs

Yang Song , Zhang Yaoting , Yin Jiantuan .

Center of tuberculosis affiliated to Nanjing Military Command , 175 th hospital, PLA , Zhangzhou city, Zhangzhou 363000 , China

Online:2007-01-10 Published:2007-11-03

摘要/Abstract

摘要： 目的探讨复方甘草甜素对抗结核治疗的药物性肝炎的预防作用。方法采用前瞻性研究,对168例住院的肺结核患者随机分为治疗组和对照组,前者予复方甘草甜素和抗结核药物联合治疗,后者进行常规抗结核治疗,观察药物性肝炎的发生情况。结果加用复方甘草甜素后,84例肺结核患者发生药物性肝炎2例,病情轻,而对照组发生药物性肝炎12例,重症1例,发生率分别为2．4％和14．3％,其中10例药物性肝炎发生于强化期,表现为乏力、恶心、呕吐、纳差、黄疸、腹胀、肝痛等。结论复方甘草甜素可有效预防抗结核治疗的药物性肝炎。

关键词: 结核,肺, 抗结核药, 肝炎, 复方甘草甜素

Abstract: Objective To study the preventive effect of glycyrrhizin on the hepatitis resulted from anti-tuberculous drugs. Methods Prospective study was adopted. One hundred and sixty-eight inpatients with pulmonary tuberculosis were randomly divided into treatment group and control group. The former was treated with glycyrrhizin combining with anti-tuberculous drugs, while the latter was treated with routine anti-tuberculous drugs. The occurrence of the hepatitis suffered from anti-tuberculous drugs was observed. Results Two of 84 cases in the treatment group were suffered from the hepatitis, whose state were not severe. Otherwise, 12 of 84 cases in the control group were suffered from the hepatitis, in which one case had severe state. The incidence of hepatitis from anti-tuberculous drugs in the two groups was 2.4% and 14.3% ,respectively. The hepatitis in ten inpatients occurred during the enhanced anti-tuberculous period,which the clinical manifestations were tiredness, nausea,vomit,icterus,windy feeling,pain in liver. Conclusion Glycyrrhizin might play a role in the prevention from anti-tuberculous drugs’ hepatitis.

Key words: Pulmonary tuberculosis, Anti-tuberculous drug, Hepatitis, Glycynhizin

杨松,张耀亭,殷建团,. 复方甘草甜素对抗结核治疗的药物性肝炎的预防效果观察[J]. 中国防痨杂志, 2007, 29(1): 19-21.

Yang Song , Zhang Yaoting , Yin Jiantuan .. Preventive effect of glycyrrhizin on the hepatitis resulted from antituberculous drugs[J]. Chinese Journal of Antituberculosis, 2007, 29(1): 19-21.

[1]	张静, 陈曦, 王彬, 付雷, 陆宇, 陈效友. 改良单叠氮丙啶-荧光定量PCR法的建立及其检测抗结核药物活性的价值[J]. 中国防痨杂志, 2020, 42(5): 472-480.
[2]	高天慧,舒薇,高静韬,陆宇,李琦. 254例耐药肺结核患者克拉霉素耐药情况及影响因素分析[J]. 中国防痨杂志, 2020, 42(3): 259-265.
[3]	陈浩,武楠楠,胡文辉,杨忠金. 抗结核药物作用新靶点及其研究进展[J]. 中国防痨杂志, 2020, 42(3): 286-292.
[4]	王静,张蒙,贺建清. 抗结核药物引起的艰难梭状芽胞杆菌相关性腹泻一例并文献复习[J]. 中国防痨杂志, 2020, 42(3): 293-296.
[5]	邱磊,张少言,郭晓燕,付际游,田黎明,张惠勇,鹿振辉. 化疗方案加芩部丹片治疗复治涂阳肺结核患者的临床价值[J]. 中国防痨杂志, 2020, 42(2): 108-114.
[6]	王雪迪,江锋,代倩兰,王京,王冬梅. 中西医联合与单纯西医治疗结核病所致药物性肝损伤的对比分析(2000—2019年文献复习)[J]. 中国防痨杂志, 2020, 42(2): 126-132.
[7]	李蒙, 路丽苹, 江琦, 洪建军, 高谦, 杨崇广, 郭晓芹. 上海市松江区肺结核患者治疗药品的种类及费用分析[J]. 中国防痨杂志, 2020, 42(12): 1329-1332.
[8]	唐亮, 鲍玉成, 张文龙. 抗结核药品对肠道菌群的改变及其对机体的影响[J]. 中国防痨杂志, 2020, 42(12): 1333-1338.
[9]	陈曦,刘忠泉,王彬,朱慧,付雷,李媛媛,陆宇. 14种抗结核药物在巨噬细胞内的抗结核活性评价[J]. 中国防痨杂志, 2019, 41(9): 993-998.
[10]	《中国防痨杂志》编委会. 耐药结核病化疗过程中药品不良反应处理的专家共识[J]. 中国防痨杂志, 2019, 41(6): 591-603.
[11]	邓国防,张培泽,杨敏,付亮. 二线注射剂治疗耐多药结核病的现状与思考[J]. 中国防痨杂志, 2019, 41(6): 604-608.
[12]	赵皎洁,陆宇. 抗结核药物药代动力学/药效学的研究及进展[J]. 中国防痨杂志, 2019, 41(6): 700-704.
[13]	郭存炳,李辉,郑淑兰. 参芪十一味颗粒治疗抗结核药物所致白细胞减少症的疗效[J]. 中国防痨杂志, 2018, 40(3): 274-279.
[14]	吴虹，李钧，安琴，等. 水飞蓟宾胶囊预防抗结核药物所致肝损伤的疗效分析[J]. 中国防痨杂志, 2017, 39(7): 757-760.
[15]	赵嫄，雷倩，党丽云，等. 抗结核药物血药浓度监测工作的思考和展望[J]. 中国防痨杂志, 2017, 39(11): 1228-1232.