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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (3): 293-296.doi: 10.3969/j.issn.1000-6621.2020.03.021

• 短篇论著 • 上一篇    下一篇



  1. 610041 成都,四川大学华西医院呼吸与危重症医学科
  • 收稿日期:2019-11-30 出版日期:2020-03-10 发布日期:2020-03-18
  • 通信作者: 贺建清
  • 基金资助:

Clostridium difficile-associated diarrhea caused by anti-tuberculosis drugs: a case report and literature review

WANG Jing,ZHANG Meng,HE Jian-qing()   

  1. Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
  • Received:2019-11-30 Online:2020-03-10 Published:2020-03-18
  • Contact: Jian-qing HE



关键词: 结核, 肺, 抗结核药, 芽孢杆菌, 腹泻, 总结性报告(主题)


Antimicrobial agent exposure is a risk factor for Clostridium difficile-associated diarrhea (CDAD), whereas the use of anti-tuberculous (anti-TB) drugs is rarely associated with it. This article reports a case of CDAD associated with anti-TB drugs, and reviews relevant literatures. A 32-year-old woman with pulmonary tuberculosis who had been treated with anti-TB agents for 9 months was admitted for abdominal pain and diarrhea. The test results of Clostridium difficile toxin and glutamate dehydrogenase (GHD) were both positive. Symptoms were relieved after anti-TB drugs were discontinued and treatment with vancomycin and bifidobacterium was given for 9 days. By reviewing literatures, the authors have discussed the pathogenesis, clinical manifestations, diagnosis and treatment of CDAD, in order to remind clinicians to understand the rare complications in the process of tuberculosis treatment, and to avoid pseudomembranous colitis (PMC) and other serious intestinal diseases by early diagnosis and intervention.

Key words: Tuberculosis, pulmonary, Antitubercular agents, Brevibacillus, Diarrhea, Consensus development conferences as topic