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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (9): 885-893.doi: 10.3969/j.issn.1000-6621.2020.09.001

• 指南·规范·共识 •    下一篇



  • 收稿日期:2020-06-28 出版日期:2020-09-10 发布日期:2020-09-18
  • 基金资助:

Expert consensus of clinical application of fixed-dose combination formulations

Academic Working Committee of Chinese Antituberculosis Association, Editorial Board of Chinese Journal of Antituberculosis   

  • Received:2020-06-28 Online:2020-09-10 Published:2020-09-18



关键词: 抗生素类, 抗结核, 固定剂量复合制剂, 治疗应用, 专家共识


The global modern tuberculosis control strategy puts forward that the anti-tuberculosis drugs should be continuously supplied to the patients with pulmonary tuberculosis, and the standardized short-term chemotherapy regimen and the whole-course management should be implemented to the patients with new pulmonary tuberculosis. The purpose is to improve the regular treatment rate and cure rate of the patients with pulmonary tuberculosis. In order to further improve the treatment compliance of patients with tuberculosis, reduce the number of drugs taken by patients each time, simplify the prescription of medicine prescribed by doctors, and prevent the occurrence of drug-resistant tuberculosis caused by unreasonable prescription and dosage. In 1994, WHO and IUATLD recommended the use of fixed dose combination (FDC) of anti-tuberculotic drugs in patients with tuberculosis. Since the beginning of this century, China had carried out a number of implementation studies on the application of FDC consecutively in different provinces. The results show the feasibility and effectiveness of FDC in the treatment of tuberculosis, and provide an important scientific basis for FDC to be included in the national tuberculosis control program. This consensus has been repeatedly discussed by experts in the fields of tuberculosis prevention and control, clinicians and researchers. Based on the significance of use, pharmacodynamics and pharmacokinetics, a number of application research results of FDC, preparation types and specifications of FDC, and suggestions for clinical use of FDC in China, the experts formed ‘the consensus on clinical use of fixed dose combinations of anti-tuberculosis drugs’ which provides reference for formulating the use strategy of anti-tuberculosis drugs and the treatment of tuberculosis patients in China.

Key words: Antibiotics, antituberculosis, Fixed dose combination, Therapeutic uses, Expert consensus