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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (3): 286-292.doi: 10.3969/j.issn.1000-6621.2020.03.020

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  1. 511436 广州医科大学药学院蛇毒与生物毒素研究所
  • 收稿日期:2019-10-24 出版日期:2020-03-10 发布日期:2020-03-18
  • 通信作者: 胡文辉,杨忠金;
  • 基金资助:

Research progress of new targets for antituberculosis agents

CHEN Hao,WU Nan-nan,HU Wen-hui(),YANG Zhong-jin()   

  1. Research Institute of Snake Venom,School of Pharmaceutical Sciences,Guangzhou Medical University,Guangzhou 511436,China
  • Received:2019-10-24 Online:2020-03-10 Published:2020-03-18
  • Contact: Wen-hui HU,Zhong-jin YANG;



关键词: 抗结核药, 新靶点, 新型化合物, 研究进展


Tuberculosis remains a health problem that threatens our country and the world. Bacterial resistance is becoming more and more serious due to bacterial mutations, irrational treatment options, and drug abuse, and drug-resistant tuberculosis has threatened the health and safety of all human beings. In the past decade,many new anti-tuberculosis drugs targeting various new targets of Mycobacterium tuberculosis have been gradually started clinical trials. This review analyzes the new targets for cell wall synthesis, protein synthesis and energy metabolism in the study of anti-Mycobacterium tuberculosis and briefly introduce some related new compounds,in order to provide reference for the development of anti-tuberculosis drugs.

Key words: Antitubercular agents, New targets, Novel compounds, Research progress