结核分枝杆菌细胞外RNA的研究现状

doi:10.3969/j.issn.1000-6621.2020.11.019

摘要/Abstract

摘要：

结核分枝杆菌引起的结核病,已成为全球十大死因之一。对于结核病,我们迫切需要更早期的诊断和更有效的治疗方法。细胞外RNA(extracellular RNA,exRNA)在作为多种疾病生物标志物和治疗手段上,表现出巨大的潜力。为了后续探讨结核分枝杆菌exRNA在结核病诊断及治疗方面的应用,作者总结了目前结核分枝杆菌exRNA的研究现状,并讨论了结核分枝杆菌exRNA的产生机制,希望对结核分枝杆菌exRNA的探究提供有利的帮助。

关键词: 分枝杆菌,结核, 细胞外RNA, 诊断, 治疗应用

Abstract:

Tuberculosis has become one of the ten leading causes of death in the world. For tuberculosis,we urgently need an earlier diagnosis and a more effective treatment. Extracellular RNA (exRNA) has great potential as a biomarker and treatment for many diseases. In order to follow up on the application of Mycobacterium tuberculosis exRNA in the diagnosis and treatment of tuberculosis,we summarize the current research progress of Mycobacterium tuberculosis exRNA and discusse the production mechanism of Mycobacterium tuberculosis exRNA,hopefully to provide a favorable understanding for the exploration of Mycobacterium tuberculosis exRNA.

Key words: Mycobacterium tuberculosis, Extracellular RNA, Diagnosis, Therapeutic uses

李婷, 范云帆, 付英梅. 结核分枝杆菌细胞外RNA的研究现状[J]. 中国防痨杂志, 2020, 42(11): 1250-1253. doi: 10.3969/j.issn.1000-6621.2020.11.019

LI Ting, FAN Yun-fan, FU Ying-mei. Research progress of extracellular RNA of Mycobacterium tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(11): 1250-1253. doi: 10.3969/j.issn.1000-6621.2020.11.019

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