关键词: 胸壁, 结核, 药物疗法, 超声透入疗法, 对比研究

Abstract:

Objective To observe the treatment efficacy of drug transdermal delivery by electro-phonophoresis combined with oral anti-tuberculosis drugs in patients with tuberculosis of chest wall. Methods The prospective research method was adopted. A total of 192 patients with tuberculosis of chest wall, who received initial anti-tuberculosis treatment in the Beijing Chest Hospital from July 2012 to February 2019, were enrolled into this study. Using the random number table, those patients were randomly divided into two groups: orally taking anti-tuberculosis drugs (2H-R-Z-E/7H-R-E)+ultrasonic transdermal delivery of isoniazid and rifampin (abbreviated as “EP group”); orally taking anti-tuberculosis drugs (2H-R-Z-E/7H-R-E; abbreviated as “control group”). There were 97 patients in the EP group, 2 patients lost follow-up, and finally 95 patients were evaluated; 95 patients were enrolled in the control group, 10 patients lost follow-up, and finally 85 patients were evaluated. The therapeutic effects of the patients with chest wall tuberculosis in the two groups receiving different treatment schemes were analyzed. Results In the EP group, 64 patients were cured and the treatment efficacy was significant in additional 13 patients, so the total treatment effective rate was 81.1% (77/95). In the control group, 18 patients were cured and the treatment efficacy was significant in 2 patients, so the total treatment effective rate was 23.5% (20/85). The total treatment effective rate of the patients in the EP group was higher than that in the control group, and the difference was statistically significant (χ²=59.738, P<0.001). Conclusion The therapeutic effectiveness of transdermal ultrasound-mediated drug delivery combined with oral anti-tuberculosis drugs treatment in the patients with chest wall tuberculosis is much better than that of traditional treatment only with oral anti-tuberculosis drugs, and it can be used as an adjuvant treatment method in the patients with chest wall tuberculosis in their perioperative period.

Key words: Thoracic wall, Tuberculosis, Drug therapy, Phonophoresis, Comparative study