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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (9): 968-972.doi: 10.3969/j.issn.1000-6621.2020.09.015

• 论著 • 上一篇    下一篇

超声抗结核药品电导入联合化疗对胸壁结核的疗效观察

马廷龙, 韩毅, 程序, 刘志东()   

  1. 101149 首都医科大学附属北京胸科医院胸外二科
  • 收稿日期:2020-03-15 出版日期:2020-09-10 发布日期:2020-09-18
  • 通信作者: 刘志东 E-mail:lzdzrd@sina.com
  • 基金资助:
    北京市医院管理局临床技术创新项目(XMLX201835);北京市首都发展基金(首发2018-2-2161)

Clinical observation on treatment effectiveness of transdermal ultrasound-mediated drug delivery combined with oral anti-tuberculosis drug in patients with chest wall tuberculosis

MA Ting-long, HAN Yi, CHENG Xu, LIU Zhi-dong()   

  1. The Second Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China
  • Received:2020-03-15 Online:2020-09-10 Published:2020-09-18
  • Contact: LIU Zhi-dong E-mail:lzdzrd@sina.com

摘要:

目的 观察超声抗结核药品电导入联合化疗对胸壁结核的疗效。方法 采用前瞻性研究的方法,纳入2012年7月至2019年2月间到首都医科大学附属北京胸科医院胸外科就诊的192例初治胸壁结核患者,通过数字表法随机分为口服抗结核药品(2H-R-Z-E/7H-R-E)+超声电导入异烟肼和利福平治疗组(简称“电导组”)和单纯口服抗结核药品治疗组(2H-R-Z-E/7H-R-E)(简称“对照组”)。电导组纳入患者97例,失访2例,最终入组95例;对照组纳入患者95例,失访10例,最终入组85例。分析两种治疗方案对胸壁结核的治疗效果。结果 电导组患者中,64例获得治愈,13例疗效为显效,总有效(治愈+显效)率为81.1%(77/95);对照组患者中,18例获得治愈,2例疗效为显效,总有效率为23.5%(20/85)。电导组总有效率明显高于对照组,差异有统计学意义(χ2=59.738,P<0.001)。结论 胸壁结核超声抗结核药品电导入联合口服抗结核药品应用于胸壁结核的治疗,疗效优于传统的口服抗结核药品治疗,可以作为胸壁结核围手术期抗结核治疗的方法。

关键词: 胸壁, 结核, 药物疗法, 超声透入疗法, 对比研究

Abstract:

Objective To observe the treatment efficacy of drug transdermal delivery by electro-phonophoresis combined with oral anti-tuberculosis drugs in patients with tuberculosis of chest wall. Methods The prospective research method was adopted. A total of 192 patients with tuberculosis of chest wall, who received initial anti-tuberculosis treatment in the Beijing Chest Hospital from July 2012 to February 2019, were enrolled into this study. Using the random number table, those patients were randomly divided into two groups: orally taking anti-tuberculosis drugs (2H-R-Z-E/7H-R-E)+ultrasonic transdermal delivery of isoniazid and rifampin (abbreviated as “EP group”); orally taking anti-tuberculosis drugs (2H-R-Z-E/7H-R-E; abbreviated as “control group”). There were 97 patients in the EP group, 2 patients lost follow-up, and finally 95 patients were evaluated; 95 patients were enrolled in the control group, 10 patients lost follow-up, and finally 85 patients were evaluated. The therapeutic effects of the patients with chest wall tuberculosis in the two groups receiving different treatment schemes were analyzed. Results In the EP group, 64 patients were cured and the treatment efficacy was significant in additional 13 patients, so the total treatment effective rate was 81.1% (77/95). In the control group, 18 patients were cured and the treatment efficacy was significant in 2 patients, so the total treatment effective rate was 23.5% (20/85). The total treatment effective rate of the patients in the EP group was higher than that in the control group, and the difference was statistically significant (χ2=59.738, P<0.001). Conclusion The therapeutic effectiveness of transdermal ultrasound-mediated drug delivery combined with oral anti-tuberculosis drugs treatment in the patients with chest wall tuberculosis is much better than that of traditional treatment only with oral anti-tuberculosis drugs, and it can be used as an adjuvant treatment method in the patients with chest wall tuberculosis in their perioperative period.

Key words: Thoracic wall, Tuberculosis, Drug therapy, Phonophoresis, Comparative study