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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (5): 503-509.doi: 10.3969/j.issn.1000-6621.2020.05.016

• 论著 • 上一篇    下一篇


任哲雯, 张国龙, 龚德华, 雷蓉蓉, 祖筱雯, 徐彩红, 夏愔愔, 张灿有, 陈卉, 成君(), 张慧()   

  1. 102206 北京,中国疾病预防控制中心结核病预防控制中心(任哲雯、祖筱雯、徐彩红、夏愔愔、张灿有、 陈卉、成君、张慧);河南省疾病预防控制中心结核病控制所(张国龙);湖南省胸科医院防治部(龚德华);重庆市结核病防治所区县防治科(雷蓉蓉)
  • 收稿日期:2020-03-06 出版日期:2020-05-10 发布日期:2020-05-08
  • 通信作者: 成君,张慧;
  • 基金资助:

Acceptability of preventive treatment with 12-week regimen among close contacts of tuberculosis

REN Zhe-wen, ZHANG Guo-long, GONG De-hua, LEI Rong-rong, ZU Xiao-wen, XU Cai-hong, XIA Yin-yin, ZHANG Can-you, CHEN Hui, CHENG Jun(), ZHANG Hui()   

  1. National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
  • Received:2020-03-06 Online:2020-05-10 Published:2020-05-08
  • Contact: CHENG Jun,ZHANG Hui;


目的 了解确定为结核潜伏感染的肺结核密切接触者对12周预防性治疗方案的接受意愿及影响因素,为在我国潜伏感染的肺结核密切接触者中逐步推广预防性治疗措施提供参考依据。方法 选取2018年1月1日至2020年1月15日“十三五”国家科技重大专项课题(肺结核患者密切接触者潜伏感染干预技术研究)中纳入的病原学阳性肺结核患者1087例,对上述患者密切接触者中5~65周岁确定为潜伏感染者1033例,在知情同意的基础上进行问卷调查,以了解其对12周预防性治疗方案的接受意愿及其影响因素。问卷主要内容包括潜伏感染的肺结核密切接触者社会人口学基本信息、结核病防治知识知晓情况、结核病接触史、其指示病例的结核病症状,以及是否愿意进行预防性服药等。一共发放1033份问卷,收回有效问卷1033份,有效率100%。对1033例潜伏感染的肺结核密切接触者预防性服药接受意愿进行χ2检验和非条件二分类logistic回归分析。结果 在1033例潜伏感染的肺结核密切接触者中,788例(76.28%)愿意接受预防性服药。不愿意接受服药的因素是家庭人均年收入≥16000元(OR=0.42;95%CI:0.27~0.67),愿意接受服药的因素是与指示病例不共同居住(OR=1.89;95%CI:1.32~2.67)。结论 潜伏感染的肺结核密切接触者对12周预防性治疗方案的接受意愿较高,其接受意愿受家庭经济水平和与指示病例接触程度影响。

关键词: 结核,肺, 接触者追踪, 潜伏性结核病, 预防和防护用药, 接受意愿


Objective To understand the acceptability and influencing factors for 12-week preventative treatment for close contacts with latent tuberculosis infection (LTBI), and to provide more evidence for the progressive promotion of preventive treatment measures in close contacts of tuberculosis (TB) patients in China. Methods A total of 1, 087 etiologically positive TB patients enrolled in the “Thirteenth Five-Year Plan” National Science and Technology Major Project (intervention on latent infected close contacts of TB patients) from Jan 1st, 2018 to Jan 15th, 2020 were selected, among whom 1033 cases aged 5 to 65 with LTBI were enrolled in this study. Informed consent and questionnaires were conducted to understand the acceptance rate and influencing factors for the 12-week preventative treatment regimen in these 1033 cases. The main contents of the questionnaire included the social demographic information of the close contacts with LTBI, the awareness of the knowledge of TB control and prevention, the history of TB exposure, the symptoms of the index cases, and whether they were willing to take preventive medicine. A total of 1033 questionnaires were valid with the effectively response rate of 100%. Acceptability of the 1033 cases was analyzed with Chi-square test and unconditional dichotomous logistic regression test. Results Among 1033 latent infected close contacts, 788 (76.28%) were willing to take preventive medicine. The risk factor was the family’s average annual income ≥16000 yuan (OR=0.42, 95%CI:0.27-0.67), and the protective factor was not living with the index case (OR=1.89, 95%CI:1.32-2.67). Conclusion Close contacts with LTBI are much willing to accept the 12-week preventive treatment regimen, which is affected by the family’s economic level and the degree of exposure to the index cases.

Key words: Tuberculosis,pulmonary, Contact tracing, Latent tuberculosis, Protective agents, Acceptability