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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (6): 621-625.doi: 10.3969/j.issn.1000-6621.2020.06.015

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宋其生, 路希维()   

  1. 116033 大连市结核病医院
  • 收稿日期:2020-04-21 出版日期:2020-06-10 发布日期:2020-06-11
  • 通信作者: 路希维

Progress and prospect of positron emission computed tomography applied in clinical research of pulmonary tuberculosis

SONG Qi-sheng, LU Xi-wei()   

  1. Dalian Tuberculosis Hospital, Dalian 116033, China
  • Received:2020-04-21 Online:2020-06-10 Published:2020-06-11
  • Contact: LU Xi-wei


正电子发射计算机体层摄影-CT(PET-CT)扫描可对潜伏性结核感染/亚临床结核病进行早期评估,确定潜在的感染病变部位;有助于不明原因发热患者寻找病因;通过观察病变处 18F标记的氟代脱氧葡萄糖( 18F-FDG)摄取情况了解病变的炎症反应,可对结核活动性做出客观评价。在抗结核治疗过程中,通过观察病变的 18F-FDG摄取的系列变化可对治疗是否成功做出预测。但由于其价格昂贵等问题,目前该技术尚不具备临床广泛应用的条件;不过基于其技术优势,有望在结核病临床与基础研究中发挥作用。

关键词: 潜伏性结核病, 结核, 正电子发射断层显像术, 体层摄影术, X线计算机, 诊断显像, 评论


Positron emission computed tomography-CT (PET-CT) scan can be used for evaluating the latent tuberculosis (TB) infection/subclinical TB infection in early stage, identifying the potential infectious lesions, finding the etiological factors in patients with unexplained fever, comprehending the inflammatory reaction of lesions by observing the uptake of fluorodeoxyglucose ( 18F-FDG), and making an objective evaluation of TB activity. During the course of anti-TB treatment, the success of the treatment can be predicted by observing the series of changes of 18-FDG uptake of the lesion. However, due to the high price and other issues, the widespread clinical application of PET-CT is limited. Nevertheless, based on the technical advantages of PET-CT, it is still expected to play an important role in clinical and scientific research of TB.

Key words: Latent tuberculosis, Tuberculosis, Positron-emission tomography, Tomography, X-ray computed, Diagnostic imaging, Comment