关键词: 老年, 抗结核药, 肝炎,中毒性

Abstract: Objective To study the characteristics of drug-induced liver injury caused by anti-tuberculosis drugs in the geriatric tuberculosis patients Method The frequency of drug-induced liver injury during the treatment with anti-tuberculosis drugs was calculated in the test group and control group.The frequency,the degree,the cause,the appearance of drug-induced liver injury caused by anti-tuberculosis drugs and the difference of clinic symptom between the two groups were compared.The software SPSS11.0 was used to deal with the data,and there is significant difference if P<0.05.The clinical symptom,the frequency and the cases whose ALT was? Result over 200U and with jaundice in the test group were more than those in the control group, and the cases whose ALT was between 120～200U were less than the control group (P<0.05),and the difference between the two groups was significant.The data from the two groups showed that the drug-induced liver injury was mostly caused by Rifampicin,the fastigium of drug-induced liver injury appeared after 2～4 weeks.There was no difference in the proportion of the three anti-tuberculosis drugs which caused the liver injury,the appearance and the appearing time of drug-induced liver injury between the two groups. Conclusion The frequency of liver injury is higher and degree of liver injury is more serious in the geriatric tuberculosis patients.

Key words: The elderly, Antitubercular agents, Hepatitis,toxic