抗结核药物组合药效筛选研究进展

doi:10.3969/j.issn.1000-6621.2021.04.018

摘要/Abstract

摘要：

结核病至今仍是一个深受全球关注的健康问题。由于抗结核治疗需要组合用药,临床迫切需要开发有效的药物组合方案以提高治疗效果及缩短疗程。最佳药物组合方案的确定首先要经体外筛选,再通过体内实验进行验证。笔者就近年来抗结核药物组合及体内外筛选方法进行综述,以期为结核病的临床治疗提供快速有效的药物组合方案。

关键词: 抗结核药, 药物疗法,联合, 体外研究, 综述文献(主题)

Abstract:

Tuberculosis remains a global health concern. Because anti-tuberculosis treatment need drug combination, it is urgent to develop effective regimen with drug combination to improve the therapeutic effect and shorten the course of treatment. The determination of the best drug combination regimen must first be screened in vitro and then verified by in vivo experiments. This article reviews the anti-tuberculosis drug combinations and screening methods in vivo and in vitro in recent years, in order to provide a rapid and effective drug combination regimen for the treatment of clinical tuberculosis in the practice.

Key words: Antitubercular agents, Drug therapy, combination, In vitro, Review litera-ture as topic

刘海婷, 陆宇. 抗结核药物组合药效筛选研究进展[J]. 中国防痨杂志, 2021, 43(4): 404-408. doi: 10.3969/j.issn.1000-6621.2021.04.018

LIU Hai-ting, LU Yu. Progress in pharmacodynamic screening of anti-tuberculosis drug combination[J]. Chinese Journal of Antituberculosis, 2021, 43(4): 404-408. doi: 10.3969/j.issn.1000-6621.2021.04.018

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