关键词: 结核,肺, 抗药性, 细菌, 问卷调查, 广东省

Abstract: Objective To understand the prevalence and characteristic of drug-resistant tuberculosis(DR-TB) in Guangdong province in order to provide evidence base for strategy development.
Methods Smear positive PTB patients were sampled by two-stage random sampling methods.The clinical information of patients were collected through questionnaires and proportion methods were employed in drug susceptibility test(DST) for rifampicin,isoniazid,streptomycin,ethambutol,ofloxacin and kanamycin. Results 1)This study found a total of 45 cases of non-tuberculous mycobacteria infection,accounting for 2.2% of all culture positive cases,among which 28 were new smear positive cases and 17 were retreatment cases. 2)The total drug-resistant rate(DRR) were 16.4%,acquired DRR(22.5%) were higher than primary DRR(14.1%)(χ²=17.9, P<0.01).Multidrug-resistant rate(MDRR) were 4.9%,with higher acquired MDRR(8.2%) than primary MDRR(3.6%)(χ²=13.6, P<0.01).28.9% of MDR-TB cases were proved to be extensively drug-resistant tuberculosis(XDR-TB) which were 1.4% of total. 3) Compared with that of 1998,the DRR and MDRR were decreased by 16.2% and 23.3% respectively so far. 4) Through the DST of six drugs,35 types of drug-resistant spectrum were found including 5 types of single DR,19 types of poly-resistant and 12 types of MDR(including 2 types of XDR-TB).Conclusions 1) Although the DR-TB epidemic showed a overall downward trend,Guangdong province still have a high burden of DR-TB and face the challenge from MDR-TB and XDR-TB. 2) The polymorphism and complexity of the drug resistance spectrum calls for a more urgent and more comprehensive interventions against the prevalence of DR-TB in Guangdong province.

Key words: rculosis,pulmonary, Drug resistance,bacterial, Questionnaires, Guangdong province