经支气管镜介入冷冻技术在呼吸系统疾病应用中的研究进展

doi:10.3969/j.issn.1000-6621.2019.03.018

摘要/Abstract

摘要：

冷冻治疗古已有之。随着医疗器械、临床技术的不断发展,冷冻技术因其特有的优势在临床应用中占据着重要地位。冷冻不仅应用于皮肤表面疾病的治疗,而且也用于肺部肿瘤、胃部肿瘤等体内脏器疾病的治疗。此外,各种内镜腔内冷冻技术也在不断发展,扩大了冷冻在临床中的应用范围。其中经支气管镜冷冻治疗就用于多种临床疾病,包括恶性和良性中央气道阻塞的治疗,异物清除或支气管结核的治疗和支气管内活检等。有关研究证实了冷冻技术在气道疾病治疗中的有效性。作者就近年来经支气管镜介入冷冻技术在呼吸系统疾病中的应用及进展进行综述,以期相关临床工作者更加全面地了解经支气管镜介入冷冻技术的特点。

关键词: 冷冻疗法, 支气管镜, 治疗应用, 呼吸系统, 综述

Abstract:

Cryotherapy has existed in ancient times. With the development of medical devices and clinical technology, cryotechnique plays an important role in clinical application because of its unique advantages. Cryotherapy is not only used in the treatment of skin surface diseases,but also in the treatment of lung tumors, stomach tumors and other diseases of internal organs. In addition, cryotechnique through various endoscopes is also developing,and expands the scope of clinical application of cryotherapy. Cryotherapy through bronchoscope has been used for endobronchial biopsy and treatment of many diseases,such as malignant and benign central airway obstruction,removal of foreign bodies, bronchial tuberculosis. Studies have confirmed the effectiveness of cryotechnique in treatment of airway diseases. The application and progress of cryotherapy through bronchoscopy in respiratory diseases are reviewed.

Key words: Cryotherapy, Bronchoscopes, Therapeutic uses, Respiratory system, Review

王蓉蓉,陈志,张广宇. 经支气管镜介入冷冻技术在呼吸系统疾病应用中的研究进展[J]. 中国防痨杂志, 2019, 41(3): 343-347. doi: 10.3969/j.issn.1000-6621.2019.03.018

Rong-rong WANG,Zhi CHEN,Guang-yu ZHANG. Progress of cryotechnique through bronchoscope in respiratory diseases[J]. Chinese Journal of Antituberculosis, 2019, 41(3): 343-347. doi: 10.3969/j.issn.1000-6621.2019.03.018

参考文献 45

[1]	Mathur PN, Wolf KM, Busk MF , et al. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest, 1996,110(3):718-723. doi: 10.1378/chest.110.3.718 URL
[2]	Cooper IS, Lee AS . Cryostatic congelation:A system for producing a limited controlled region of cooling or freezing of biologic tissues. J Nerv Ment Dis, 1961,133:259-263. doi: 10.1097/00005053-196109000-00013 URL
[3]	Neel HB 3rd, Farrell KH, DeSanto LW , et al. Cryosurgery of respiratory structures. The Laryngoscope, 1973,83(7):1062-1071. doi: 10.1288/00005537-197307000-00007 URL pmid: 4719356
[4]	陈志, 张广宇, 王巍 . 支气管镜介入技术在支气管结核治疗中的应用进展. 中国防痨杂志, 2011,33(8):507-511.
[5]	Mudambi L, Miller R, Eapen GA . Malignant central airway obstruction. J Thorac Dis, 2017,9 Suppl 10: S1087-1110. doi: 10.21037/jtd URL
[6]	Dhooria S, Sehgal IS, Behera D , et al. Transbronchial lung biopsy with a flexible cryoprobe during rigid bronchoscopy:Standardizing the procedure. Lung Indian, 2016,33(2):248-249. doi: 10.4103/0970-2113.177463 URL pmid: 27051127
[7]	Mazur P . Physical and chemical changes during freezing and thawing of cells,with special reference to blood cells. Bibl Heamatol, 1968,29:764-777.
[8]	Gilbert JC, Onik GM, Hoddick WK , et al. Real time ultrasonic monitoring of hepatic cryosurgery. Cryobiology, 1985,22(4):319-330. doi: 10.1016/0011-2240(85)90179-8 URL pmid: 3896654
[9]	张捷, 王长利 . 支气管镜发展史. 中华医史杂志, 2006,36(2):96-99. doi: 10.3760/cma.j.issn.0255-7053.2006.02.008 URL
[10]	Ikeda S, Yanai N, Ishikawa S . Flexible bronchofiberscope. Keio J Med, 1968,17(1):1-16. doi: 10.2302/kjm.17.1 URL
[11]	姜友定, 陈穗 . 支气管镜的应用进展. 中华肺部疾病杂志(电子版), 2015,8(3):384-387. doi: 10.3877/cma.j.issn.1674-6902.2015.03.032 URL
[12]	Zias N, Chroneou A, Gonzalez AV , et al. Changing patterns in interventional bronchoscopy. Respirology, 2009,14(4):595-600. doi: 10.1111/j.1440-1843.2009.01490.x URL pmid: 19383115
[13]	陈志 . 支气管介入治疗新型冷冻探针的研发. 北京:北京市结核病胸部肿瘤研究所, 2011.
[14]	陈楠, 张杰 . 气道内冷冻切除及冷冻活检. 中华结核和呼吸杂志, 2011,34(6):459-461. doi: 10.3760/cma.j.issn.1001-0939.2011.06.017 URL
[15]	Franke K, Theegarten D, Hann von Weyhern C , et al. Prospective controlled animal study on biopsy sampling with new flexible cryoprobes versus forceps:evaluation of biopsy size,histological quality and bleeding risk. Respiration, 2010,80(2):127-132. doi: 10.1159/000287251 URL
[16]	DiBardino DM, Lanfranco AR, Haas AR . Bronchoscopic Cryotherapy-Clinical Applications of the Cryoprobe, Cryospray, and Cryoadhesion. Ann Am Thorac Soc, 2016,13(8):1405-1415. doi: 10.1513/AnnalsATS.201601-062FR URL pmid: 27268274
[17]	Fernando HC, Dekeratry D, Downie G , et al. Feasibility of spray cryotherapy and balloon dilation for non-malignant strictures of the airway. Eur J Cardiothorac Surg, 2011,40(5):1177-1180. doi: 10.1016/j.ejcts.2011.02.062 URL pmid: 21482131
[18]	Robert Browning J, Francis Turner Jr, Scott Parrish . Spray cryotherapy(SCT): institutional evolution of techniques and clinical practice from early experience in the treatment of malignant airway disease. J Thorac Dis, 2015,7 Suppl 4: S405-414. doi: 10.3978/j.issn.2072-1439.2015.12.07 URL pmid: 26807288
[19]	Hetzel J, Hetzel M, Hasel C , et al. Old meets modern: The use of traditional cryoprobes in the age of molecular biology. Respiration, 2008,76(2):193-197. doi: 10.1159/000135934 URL pmid: 18708736
[20]	陈慧冬, 詹枝华 . 经支气管镜冷冻活检在中央型肺癌中的诊断价值. 临床肺科杂志, 2016,21(5):896-899. doi: 10.3969/j.issn.1009-6663.2016.05.036 URL
[21]	黄江, 夏前明, 都刚 , 等. 支气管镜冷冻活检在肺癌诊断中的临床研究. 中华肺部疾病杂志, 2010,3(3):177-181. doi: 10.3877/cma.j.issn.1674-6902.2010.03.006 URL
[22]	Aktas Z, Gunay E, Hoca NT , et al. Endobronchial cryobiopsy or forceps biopsy for lung cancer diagnosis. Ann Thorac Med, 2010,5(4):242-246. doi: 10.4103/1817-1737.69117 URL pmid: 2954380
[23]	Dhooria S, Bal A, Sehgal IS , et al. Transbronchial lung biopsy with a flexible cryoprobe: First case report from India. Lung India, 2016,33(1):64-68. doi: 10.4103/0970-2113.173066 URL pmid: 4748668
[24]	Hetzal J, Eberhardt R, Herth FJ . Cryobiopsy increases the diagnostic yield of endobronchial biopsy: a multicentre trial. Eur Respir J, 2012,39(3):685-690. doi: 10.1183/09031936.00033011 URL pmid: 21852332
[25]	陶峰, 刘加良, 张齐 , 等. 支气管镜冷冻肺活检对中老年弥漫性肺疾病的诊断价值. 全科医学临床与教育, 2017,15(3):276-278. doi: 10.13558/j.cnki.issn1672-3686.2017.03.011 URL
[26]	Kebbe J, Abdo T . Interstitial lung disease:the diagnostic role of bronchoscopy. J Thorac Dis, 2017,9 Suppl 10: S996-1010. doi: 10.21037/jtd.2017.06.39 URL pmid: 29214060
[27]	Babiak A, Hetzel J, Krishna G , et al. Transbronchial cryobio-psy: a new tool for lung biopsies. Respiration, 2009,78(2):203-208. doi: 10.1159/000203987 URL pmid: 19246874
[28]	Tomic R, Podgaetz E, Andrade RS , et al. Cryotechnology in diagnosing and treating lung diseases. J Bronchology Interv Pulmonol, 2015,22(1):76-84. doi: 10.1097/LBR.0000000000000103 URL pmid: 25590490
[29]	Rodrigues AJ, Oliveira EQ, Scordamaglio PR , et al. Flexible bronchoscopy as the first-choice method of removing foreign bodies from the airways of adults. J Bras Pneumol, 2012,38(3):315-320. doi: 10.1590/S1806-37132012000300006 URL
[30]	Pan H, Lu Y, Shi L , et al. Similarities and differences in aspirated tracheobronchial foreign bodies in patients under the age of 3 years. Int J Pediatr Otorhinolaryngol, 2012,76(6):911-914. doi: 10.1016/j.ijporl.2012.03.002 URL pmid: 22459033
[31]	Dong YC, Zhou GW, Bai C , et al. Removal of tracheobronchial foreign bodies in adults using a flexible bronchoscope:experience with 200 cases in China. Intern Med, 2012,51(18):2515-2519. doi: 10.2169/internalmedicine.51.7672 URL pmid: 22989820
[32]	Ni C, Yu H, Han X , et al. Clinical analysis of bronchoscopic cryotherapy in 156 pediatric patients. Pediatr Int, 2017,59(1):62-67. doi: 10.1111/ped.13088 URL
[33]	Rubio E, Gupta P, Boyd M , et al. Cryoextraction:a novel approach to remove aspirated chewing gum. Ann Thorac Med, 2013,8(1):58-59. doi: 10.4103/1817-1737.105721 URL pmid: 3573560
[34]	石彬, 刘德若, 郭永庆 , 等. 经纤维支气管镜冷冻治疗中、晚期中心型肺癌致气道梗阻的疗效. 中国微创外科杂志, 2008,8(11):964-966. doi: 10.3969/j.issn.1009-6604.2008.11.002 URL
[35]	Kim HR, Choi KH, Jeong ET , et al. Resection of an endobronchial hamartoma by cryotherapy. Korean J Intern Med, 2016,31(4):805-806. doi: 10.3904/kjim.2015.341 URL pmid: 4939505
[36]	Scalata S, Fuso L, Lucantoni G , et al. The technique of endoscopic airway tumor treatment. J Thorac Dis, 2017,9(8):2619-2639. doi: 10.21037/jtd.2017.07.68 URL pmid: 5594167
[37]	中华医学会结核病学分会, 《中华结核和呼吸杂志》编辑委员会. 气管支气管结核诊断和治疗指南(试行). 中华结核和呼吸杂志, 2012,35(8):585. doi: 10.3760/cma.j.issn.1001-0939.2012.08.007 URL
[38]	Mu D, Nan D, Li W , et al. Efficacy and safety of bronchoscopic cryotherapy for granular endobronchial tuberculosis. Respiration, 2011,82(3):268-272. doi: 10.1159/000322142 URL pmid: 21150172
[39]	刘福升, 徐建华, 蔡秀敏 , 等. 电子支气管镜下冷冻治疗支气管结核102例分析. 中国微创外科杂志, 2014,14(10):881-883. doi: 10.3969/j.issn.1009-6604.2014.10.004 URL
[40]	Lee JH, Ahn JH, Shin AY , et al. A promising treatment for broncholith removal using cryotherapy during flexible bronchosopy: two case reports. Tuberc Respir Dis, 2012,73(5):282-287. doi: 10.4046/trd.2012.73.5.282 URL pmid: 3517948
[41]	Campbell SN, Lala D, Rubio E . Cryotherapy: a viable tool to remove broncholiths under flexible bronchoscopy. Biomedicine (Taipei), 2016,6(4):24. doi: 10.7603/s40681-016-0024-2 URL pmid: 27848115
[42]	Jung YR, Kim SH, Lee WY , et al. Recurred post-intubation tracheal stenosis treated with bronchoscopic cryotherapy. Intern Med, 2016,55(22):3331-3335. doi: 10.2169/internalmedicine.55.6421 URL pmid: 27853078
[43]	厉银平, 彭清臻, 刘桂霞 , 等. 支气管镜高频电加冷冻治疗气管插管后狭窄6例. 临床肺科杂志, 2014,19(12):2313-2315. doi: 10.3969/j.issn.1009-6663.2014.012.063 URL
[44]	杨敏, 张晗, 罗红 , 等. 镇静下无创通气辅助支气管镜成功治疗急性呼吸衰竭患者1例. 中华危重病急救医学, 2016,28(11):1032-1034. doi: 10.3760/cma.j.issn.2095-4352.2016.11.019 URL
[45]	陈庆, 邹俊, 陈丽娟 , 等. 经支气管镜冷冻取血栓治疗安全性及疗效分析. 国际呼吸杂志, 2015,35(2):131-135. doi: 10.3760/cma.j.issn.1673-436X.2015.02.012 URL