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中国防痨杂志 ›› 2020, Vol. 42 ›› Issue (5): 523-526.doi: 10.3969/j.issn.1000-6621.2020.05.019

• 短篇论著 • 上一篇    下一篇

11例儿童气管支气管结核支气管镜诊断与介入治疗效果观察

宾松涛, 王继, 谭力, 吴澄清, 王艳春, 李明()   

  1. 650011 昆明市儿童医院 昆明医科大学附属儿童医院呼吸内科
  • 收稿日期:2019-11-10 出版日期:2020-05-10 发布日期:2020-05-08
  • 通信作者: 李明 E-mail:liming@etyy.cn

Observation on the effects of bronchoscopy diagnosis and interventional treatment in 11 children with tracheobronchial tuberculosis

BIN Song-tao, WANG Ji, TAN Li, WU Cheng-qing, WANG Yan-chun, LI Ming()   

  1. Children’s Hospital of Kunming Medical University, Yunnan Province, Kunming 650011, China
  • Received:2019-11-10 Online:2020-05-10 Published:2020-05-08
  • Contact: LI Ming E-mail:liming@etyy.cn

摘要:

为观察电子支气管镜诊断与介入治疗儿童气管支气管结核(TBTB)的效果,笔者收集2018年1月至2019年10月于昆明市儿童医院住院并进行支气管镜诊断和介入治疗的11例TBTB患儿作为研究对象。研究对象先通过影像学检查,结核菌素皮肤试验,γ-干扰素释放试验,痰液、胃液查结核分枝杆菌及培养;可疑者再经过支气管镜镜下观察其特异性改变并对活检组织进行病理检查,最终确诊。研究对象在非紧急情况下先行抗结核药物治疗2周后再行支气管镜介入治疗;其中,10例经电子支气管镜行钳夹术、冷冻治疗术治疗,1例经球囊扩张术及钬激光、冷冻治疗。研究对象经支气管镜检查发现肉芽增生性改变3例;干酪样坏死物破溃性改变8例,其中1例并发瘢痕性狭窄。11例患儿经支气管镜治疗2~6次/例,阻塞、狭窄的管腔恢复通畅。经追踪复查,全部患儿均介入治疗有效,均无发生气道痉挛、大出血、气胸、肺部继发感染、结核扩散等并发症。结果表明,TBTB在抗结核药物治疗的基础上,经支气管镜介入治疗可有效清除干酪样坏死物、减少肉芽增生,解除呼吸道梗阻,促进病灶吸收,从而有利于肺不张恢复,且安全可靠。

关键词: 结核, 气管, 支气管, 儿童, 支气管镜检查, 治疗结果

Abstract:

In order to observe the effects of electronic bronchoscopy diagnosis and interventional treatment in children with tracheobronchial tuberculosis (TBTB), the author collected 11 children with TBTB as the research subjects who were admitted to Kunming Children’s Hospital from January 2018 to October 2019 and underwent bronchoscopy diagnosis and interventional treatment. The subjects were examined by imaging, tuberculin skin test, γ-interferon release test, sputum culture, sputum and gastric juice detection for Mycobacterium tuberculosis and culture. Then the suspicious subjects were finally confirmed by bronchoscopy, observing the specific changes under the microscope, and pathological examination of the biopsy tissue. Subjects received bronchoscopy interventional therapy 2 weeks after antituberculosis drug treatment in non-emergency cases. Among them, 10 cases were treated by electronic bronchoscopy forceps and cryotherapy, and 1 case was treated by balloon dilatation, holmium laser and cryotherapy. The bronchoscopy revealed granulation proliferative change in 3 cases, and caseous necrotic ulceration change in 8 cases, including 1 case complicated by cicatricial stricture. The 11 cases were treated by bronchoscopy for 2-6 times/case, and the obstructed and narrowed lumen recovered unobstructed. After follow-up review, all the children were effective in interventional treatment, and there were no complications such as airway spasm, massive hemorrhage, pneumothorax, secondary pulmonary infection, and tuberculosis spread. The results showed that TBTB, on the basis of antituberculosis drug treatment, could effectively remove caseous necrosis, reduce granulation hyperplasia, relieve respiratory tract obstruction, and promote lesion absorption through bronchoscopic interventional therapy, which was conducive to the recovery of atelectasis and was safe and reliable.

Key words: Tuberculosis, Trachea, Bronchi, Child, Bronchoscopy, Treatment outcome