外泌体非编码RNA作为结核病诊断潜在生物标志物的研究进展

doi:10.3969/j.issn.1000-6621.2020.03.019

摘要/Abstract

摘要：

结核病仍然是严重危害人类健康的慢性传染性疾病,外泌体在结核病的发生发展中扮演了重要角色,非编码RNA与结核病的诊断近年也备受关注。作者阐述了外泌体与结核分枝杆菌感染、外泌体非编码RNA与结核病诊断的最新进展,旨在从外泌体非编码RNA的角度为结核病早期诊断、疗效监测、预后判断的研究提供新的思路。

关键词: 结核, 外泌体, RNA探针, 生物学标记, 综述

Abstract:

Tuberculosis is still a chronic infectious disease which is seriously harmful to human health. Exosome plays an important role in the occurrence and development of tuberculosis. Recently, more and more attention has been paid to the role of non-coding RNA in tuberculosis diagnosis. In this paper, the latest developments of exosome and Mycobacterium tuberculosis infection, exosomal non-coding RNA and tuberculosis diagnosis are reviewed, in order to provide a new idea for the study of early diagnosis, efficacy monitoring and prognosis estimation of tuberculosis from the perspective of exosomal non-coding RNA.

Key words: Tuberculosis, Exosomes, RNA probes, Biological markers, Review

高书慧,赵俊伟. 外泌体非编码RNA作为结核病诊断潜在生物标志物的研究进展[J]. 中国防痨杂志, 2020, 42(3): 282-285. doi: 10.3969/j.issn.1000-6621.2020.03.019

GAO Shu-hui,ZHAO Jun-wei. Research progress of exosomal non-coding RNA as potential biomarkers of tuberculosis[J]. Chinese Journal of Antituberculosis, 2020, 42(3): 282-285. doi: 10.3969/j.issn.1000-6621.2020.03.019

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