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中国防痨杂志 ›› 2010, Vol. 32 ›› Issue (5): 50-52.

• 论著 • 上一篇    下一篇

4种检测脑脊液结核分枝杆菌法对结核性脑膜炎诊断价值的探讨

韩利军, 闫世明, 秦桂香, 孙力, , 冯丽娜   

  1. 长春市传染病医院,长春,130123
  • 出版日期:2010-05-20 发布日期:2010-05-20

Study on the diagnostic value of four detection methods of Mycobacterium tuberculosis in cerebrospinal fluid for tuberculous meningitis

 Han Lijun; Yan Shiming; Qin Guixiang; Sun Li; Feng Lina   

  1. Changchun Infectious Hospital; Chanchun 130123; China;
  • Online:2010-05-20 Published:2010-05-20
  • Contact: Han Lijun E-mail:hanlijun1970@yahoo.cn

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摘要： 目的 探讨脑脊液抗酸杆菌涂片、3D、PhaB和PCR检测对结脑的诊断价值。 方法 检测60例结脑和30例非结脑患者脑脊液涂片、3D、PhaB和PCR阳性率，经统计学处理后，评价4种方法 对结脑诊断的灵敏度、特异度。 结果结脑组和其他组脑脊液涂片阳性率均为0，3D阳性率分别为23.3%和0，PhaB的阳性率分别是23.3%和26.7%，PCR的阳性率分别是6%和0，4种方法差异无统计学意义。脑脊液3D灵敏度为23.3%，特异度为100%，PhaB灵敏度为23.3%，特异度为73.3%，PCR的灵敏度10%，特异度为100%。 结论 脑脊液结核分枝杆菌涂片、3D、PhaB和PCR 4种检测方法 灵敏度低，积极寻找脑脊液结核分枝杆菌的检测方法 和提高阳性率是实验室亟需解决的问题。

关键词: 结核, 脑膜/诊断, 脑脊髓液, 分枝杆菌

Abstract: Objective To evaluate the diagnostic value of smear, 3D, PhaB and PCR to detectMycobacterium tuberculosisin cerebrospinal fluid for tuberculous meningitis.  Methods The positive rates of smear, 3D, PhaB and PCRto detectMycobacterium tuberculosisin cerebrospinal fluid were analyzed in 60 patients with tuberculous meningitis and 30 patients with non-tuberculous meningitis. The sensitivity and specificity of four detection Methods for tuberculous meningitis were also evaluated by statistical analysis. Results The positive rate in tuberculous meningitis group and the other group were 0 both in smear,23.3% and 0 in 3D,23.3% and 26.7% in PhaB and6% and 0 in PCR. The differences of four Methods in different groups were not statistically significant. Thesensitivity and specificity were 23.3% and 100% in 3D, 23.3% and 73.3% in PhaB, 10% and 100% in PCR.  Conclusions The sensitivity of Smear, 3D, PhaB and PCR to detectMycobacterium tuberculosisin celebrospinal fluid was low. It is urgent for laboratorys to develop new Methods to detectMycobacterium tuberculosisin cerebrospinal fluid and to improve the positive rate of new Methods .

Key words: tuberculosis, meningeal/diagnosis, cerebrospinal fluid, Mycobacterium tuberculosis

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