铁死亡的分子机制及其在结核病诊疗中的潜在应用

doi:10.19982/j.issn.1000-6621.20250143

中国防痨杂志 ›› 2025, Vol. 47 ›› Issue (9): 1227-1232.doi: 10.19982/j.issn.1000-6621.20250143

铁死亡的分子机制及其在结核病诊疗中的潜在应用

陈丽瑶¹, 彭逍¹, 刘原园¹, 石金², 郭永丽¹, 鲁洁¹()

¹国家儿童医学中心首都医科大学附属北京儿童医院北京市儿科研究所儿科重大疾病研究教育部重点实验室儿童耳鼻咽喉头颈外科疾病北京市重点实验室,北京 100045
²首都医科大学附属北京胸科医院北京市结核病胸部肿瘤研究所结核二科,北京 101149

收稿日期:2025-04-09 出版日期:2025-09-10 发布日期:2025-08-27
通信作者: 鲁洁 E-mail:lujiebch@163.com
基金资助:
北京市自然科学基金(7232060);国家重点研发计划(2023YFC2307301)

The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis

Chen Liyao¹, Peng Xiao¹, Liu Yuanyuan¹, Shi Jin², Guo Yongli¹, Lu Jie¹()

¹Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
²Department Ⅱ of Tuberculosis, Beijing Chest Hospital, Capital Medical University,Beijing Tuberculosis and Thoracic Tumor Institute, Beijing 101149, China

Received:2025-04-09 Online:2025-09-10 Published:2025-08-27
Contact: Lu Jie E-mail:lujiebch@163.com
Supported by:
Beijing Natural Science Foundation(7232060);National Key Research and Development Program of China(2023YFC2307301)

摘要/Abstract

摘要：

铁死亡是一种由铁依赖性脂质过氧化作用诱导的新死亡方式,与巨噬细胞死亡及宿主-病原体相互作用密切相关,在结核病中具有重要作用。笔者系统阐述了铁死亡的定义及其核心特征,深入解析铁死亡的分子调控机制并详细论述铁死亡的重要调控通路。同时,概述了结核分枝杆菌与宿主相互作用相关的铁死亡调控机制,归纳了与结核病诊疗相关的铁死亡生物标志物,并探讨了靶向铁死亡在结核病治疗中的潜在应用前景。本文为理解结核病的发病机理提供了新视角,为开发基于铁死亡调控的结核病精准诊疗策略提供了重要的理论依据和创新思路。

关键词: 免疫, 分枝杆菌,结核, 综述文献(主题)

Abstract:

Ferroptosis is a novel form of cell death induced by iron-dependent lipid peroxidation, closely associated with macrophage death and host-pathogen interactions, playing a significant role in tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB). This review systematically described the definition and core characteristics of ferroptosis and conducted an in-depth analysis of its molecular regulatory mechanisms, and the key signaling pathways. Furthermore, it outlined the regulatory mechanisms of ferroptosis associated with MTB-host interactions, systematically summarized ferroptosis-related biomarkers for TB diagnosis and treatment, and explored the potential applications of targeting ferroptosis in TB therapeutic. This study offers new perspectives for understanding TB pathogenesis and provides an important theoretical foundation and innovative insights for developing precision-based diagnostic and therapeutic strategies targeting ferroptosis regulation.

Key words: Immunity, Mycobacterium tuberculosis, Review literature as topic

中图分类号:

R52
R392.1

陈丽瑶, 彭逍, 刘原园, 石金, 郭永丽, 鲁洁. 铁死亡的分子机制及其在结核病诊疗中的潜在应用[J]. 中国防痨杂志, 2025, 47(9): 1227-1232. doi: 10.19982/j.issn.1000-6621.20250143

Chen Liyao, Peng Xiao, Liu Yuanyuan, Shi Jin, Guo Yongli, Lu Jie. The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis[J]. Chinese Journal of Antituberculosis, 2025, 47(9): 1227-1232. doi: 10.19982/j.issn.1000-6621.20250143

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铁死亡的分子机制及其在结核病诊疗中的潜在应用

The molecular mechanisms of ferroptosis and their potential applications in the diagnosis and treatment of tuberculosis

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