中国防痨杂志 ›› 2023, Vol. 45 ›› Issue (4): 426-433.doi: 10.19982/j.issn.1000-6621.20220399
收稿日期:
2022-10-13
出版日期:
2023-04-10
发布日期:
2023-03-31
通信作者:
孙照刚
E-mail:sunzg75@163.com
基金资助:
Wang Wenjing, Sun Hong, Sun Zhaogang()
Received:
2022-10-13
Online:
2023-04-10
Published:
2023-03-31
Contact:
Sun Zhaogang
E-mail:sunzg75@163.com
Supported by:
摘要:
结核分枝杆菌(Mycobacterium tuberculosis,MTB)是引起机体发生结核感染的重大病原体。天然免疫在宿主抵抗MTB入侵过程中发挥了重要作用,机体细胞内的多种模式识别受体(pattern recognition receptors,PRR)参与了针对MTB的识别。PRR作为天然免疫的“启动器”,在识别MTB后经过信号通路的转导激活天然免疫的产生。可被PRR识别的MTB组分种类繁多,包括:DNA、脂多糖、蛋白质等。本文重点关注可被PRR识别的MTB DNA,从其来源、可被识别的PRR种类,以及PRR以MTB DNA为病原相关分子模式介导相关分子信号通路激活天然免疫的机制3个方面综述了MTB DNA经由PRR激活天然免疫的过程,并着重探讨了Toll样受体9、环鸟苷酸-腺苷酸合成酶和黑色素瘤缺乏因子2样受体等PRR激活天然免疫机制的研究进展。最后,讨论了MTB DNA的应用前景,以期为开发MTB DNA相关疫苗和结核病的诊断拓展思路。
中图分类号:
王文敬, 孙宏, 孙照刚. 结核分枝杆菌DNA介导模式识别受体激活天然免疫机制的研究进展[J]. 中国防痨杂志, 2023, 45(4): 426-433. doi: 10.19982/j.issn.1000-6621.20220399
Wang Wenjing, Sun Hong, Sun Zhaogang. Progress of innate immune mechanism activated by Mycobacterium tuberculosis DNA-mediated pattern recognition receptors[J]. Chinese Journal of Antituberculosis, 2023, 45(4): 426-433. doi: 10.19982/j.issn.1000-6621.20220399
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