肠道菌群短链脂肪酸与肺结核相关性研究进展

doi:10.19982/j.issn.1000-6621.20230079

摘要/Abstract

摘要：

短链脂肪酸是肠道菌群的主要代谢产物,主要包括甲酸、乙酸、丙酸、丁酸及其支链脂肪酸和一些盐类。研究表明,短链脂肪酸与肺结核的发生发展过程存在明显的直接相关性。肺结核导致肠道菌群失调,从而降低短链脂肪酸的丰度,进而影响宿主免疫系统和炎症因子的反应;而宿主免疫系统失调和炎症因子紊乱则会促进肺结核的发生和发展。作者对短链脂肪酸与肺结核之间的相关性,两者之间可能存在的调节机制,以及是否可以通过调节肠道菌群提高机体短链脂肪酸的丰度来达到治疗或辅助治疗肺结核的目的进行了综述。

关键词: 结核,肺, 肠杆菌科, 短链脂肪酸, 免疫系统

Abstract:

Short chain fatty acids (SCFA) are the main metabolites of the gut microbiota, mainly including formic acid, acetic acid, propionic acid, butyric acid and their branched chain fatty acids, and some salts. Research has shown that there is a significant direct correlation between SCFA and the occurrence and development of pulmonary tuberculosis. Pulmonary tuberculosis leads to imbalance of gut microbiota, thereby reducing the abundance of SCFA, which affects the host immune system and the response of inflammatory factors; the disorder of host immune system and inflammatory factor will promote the occurrence and development of pulmonary tuberculosis.The author reviewed the correlation between SCFA and pulmonary tuberculosis, the possible regulatory mechanism between them, and whether it was possible to improve the abundance of SCFA in the body by regulating intestinal flora to achieve the purpose of treatment or adjuvant treatment of pulmonary tuberculosis.

Key words: Tuberculosis, pulmonary, Enterobacteriaceae, Short-chain fatty acids, Immune system

中图分类号:

张晓萌, 李敏, 柴英辉, 周静, 雷红. 肠道菌群短链脂肪酸与肺结核相关性研究进展[J]. 中国防痨杂志, 2023, 45(7): 699-706. doi: 10.19982/j.issn.1000-6621.20230079

Zhang Xiaomeng, Li Min, Chai Yinghui, Zhou Jing, Lei Hong. Research progress on the correlation between intestinal microbiota short chain fatty acids and pulmonary tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(7): 699-706. doi: 10.19982/j.issn.1000-6621.20230079

图/表 2

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