局部载药缓释系统在脊柱结核中应用的研究进展

doi:10.19982/j.issn.1000-6621.20230064

摘要/Abstract

摘要：

局部载药缓释系统作为当前脊柱结核治疗新方式,已在实验阶段被发现可抑制局部结核分枝杆菌生长,利于病灶恢复,为治疗脊柱结核骨缺损提供了有效手段。现笔者对目前研究中常用的负载方式和载体材料进行综述,深入分析局部载药缓释系统作为一种新型给药策略在脊柱结核骨缺损修复中的应用价值,并对现有研究存在的挑战进行总结,以为载药缓释技术在脊柱结核外科治疗中的应用和今后的研究提供依据和方向。

关键词: 药物释放系统, 结核,脊柱, 综述文献(主题)

Abstract:

As a new method for the treatment of spinal tuberculosis, the local drug delivery and sustained-release system has been found in the experimental stage to inhibit the growth of local Mycobacterium tuberculosis and facilitate lesion recovery, providing an effective means for treating bone defects caused by spinal tuberculosis. The authors reviewed relevant literature to discuss the commonly used drug loading methods and drug carrier materials in current research, deeply analyzed the application value of local drug delivery and sustained-release system as a new drug delivery strategy in the repair of spinal tuberculosis bone defects, and summarized the challenges in existing research, in order to provide a basis and direction for the application of drug delivery and sustained-release system in spinal tuberculosis surgical treatment and future research.

Key words: Drug delivery systems, Tuberculosis, spinal, Review literature as topic

中图分类号:

R529.2

杨军, 邓强, 李军杰, 王雨榕, 杜健强, 陈博, 张丽娟. 局部载药缓释系统在脊柱结核中应用的研究进展[J]. 中国防痨杂志, 2023, 45(7): 707-713. doi: 10.19982/j.issn.1000-6621.20230064

Yang Jun, Deng Qiang, Li Junjie, Wang Yurong, Du Jianqiang, Chen Bo, Zhang Lijuan. Research progress on application of local drug delivery and sustained-release system in spinal tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(7): 707-713. doi: 10.19982/j.issn.1000-6621.20230064

图/表 2

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分类	常见材料	优点	缺点
无机材料	羟基磷灰石和磷酸钙骨水泥	良好的生物相容性、骨传导性、可塑性且可降解	机械强度较差,降解速度慢
高分子材料	聚乳酸、聚乙醇酸及聚乳酸/聚乙醇酸复合物等脂肪族聚酯类材料	良好的生物相容性、可塑性、无毒且可降解	脆性大、降解速度难以控制
天然有机材料	壳聚糖、胶原等天然材料	良好的生物相容性和可降解性	机械强度差、体内降解速度不受控制

药物负载方式	应用	优点	缺点
包埋法	载药微球、微囊或微乳等	载药量较高,药物释放速率可控	包封率低,成本高
溶液吸附法	多孔隙或层状载体材料	避免有机溶剂对药物的影响	载药量低,药物释放初期易发生突释现象
直接充填法	带有大空腔的载体材料	可精准控制载药量	药物释放速率过快,且不可控