中国防痨杂志 ›› 2023, Vol. 45 ›› Issue (3): 311-317.doi: 10.19982/j.issn.1000-6621.20220447
收稿日期:
2022-11-09
出版日期:
2023-03-10
发布日期:
2023-03-07
通信作者:
杨松,唐神结
E-mail:yangsong5@aliyun.com;tangsj1106@vip.sina.com
基金资助:
Zhou Feng1, Li Tongxin1, Yang Song2(), Tang Shenjie3()
Received:
2022-11-09
Online:
2023-03-10
Published:
2023-03-07
Contact:
Yang Song,Tang Shenjie
E-mail:yangsong5@aliyun.com;tangsj1106@vip.sina.com
Supported by:
摘要:
疗程是结核病患者治愈的一个关键因素,药物敏感肺结核长疗程与非依从性、随访丢失有关,耐多药结核病与治疗成功率低有关。标准6个月方案治疗药物敏感肺结核虽然高效,但也存在诸多挑战,如耐药性的增加、治疗依从性差、药物相互作用、不良反应或药代动力学差异等导致不理想的治疗结局。研发安全而有效的、缩短痰培养阴转时间、提高治愈率和治疗完成率、降低发病率、病亡率和复发率的结核病短程治疗方案至关重要。有效的结核病短程治疗方案对患者和医务人员均可获益,能提高治疗依从性、降低药物不良反应和治疗成本等。作者对敏感肺结核的缩短疗程方案,如2H-R-Z(E)/2H-R(异烟肼,isoniazid,H;利福平,rifampin,R;吡嗪酰胺,pyrazinamide,Z;乙胺丁醇,ethambutol,E)和2R7-H7-Z7-E7-Mfx7/2R7-H7-Mfx7(莫西沙星,moxifloxacin,Mfx)的4个月方案、使用的4个月方案标准剂量Mfx替代6个月标准方案中的H或E、2H-Rft-Mfx-Z/2H-Rft-Mfx(利福喷丁,rifapentine,Rft)方案,以及将耐药结核病治疗缩短至6个月疗程的方案,如新一代抗结核药物氟喹诺酮类加入标准方案中、新型抗结核药物如贝达喹啉、德拉马尼或普托马尼等新药组成的新方案、高剂量老药新用、全口服替代注射剂等缩短疗程方案,进行综述。
中图分类号:
周奉, 李同心, 杨松, 唐神结. 结核病短程治疗方案的研究进展[J]. 中国防痨杂志, 2023, 45(3): 311-317. doi: 10.19982/j.issn.1000-6621.20220447
Zhou Feng, Li Tongxin, Yang Song, Tang Shenjie. Progress on short-course regimens for the treatment of tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(3): 311-317. doi: 10.19982/j.issn.1000-6621.20220447
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