18F-氟代脱氧葡萄糖正电子发射计算机体层摄影-CT在结核病诊治中的应用价值

doi:10.19982/j.issn.1000-6621.20220500

摘要/Abstract

摘要：

结核病是全球公认的重大公共卫生问题。目前,在结核病诊疗过程中仍面临常规影像学检查难以解决的问题。¹⁸F-氟代脱氧葡萄糖正电子发射计算机体层摄影CT(¹⁸F-FDG PET/CT)是应用比较成熟的多模态显像,可同时显示解剖和代谢图像,有助于结核病的诊断,尤其在定位隐匿部位的结核病病灶方面优于常规影像学检查技术。另外,病灶的代谢情况能反映炎性细胞的活化程度,¹⁸F-FDG PET/CT能客观判断结核分枝杆菌的稳定状态和病灶活动性。在抗结核治疗过程中,¹⁸F-FDG PET/CT可先于常规影像学检测获得优于细菌学评估的早期治疗疗效。¹⁸F-FDG PET/CT实现了从代谢角度探讨结核病发生、发展及治疗的机制,提高治疗的安全性和个体化,对整合结核病的医学诊疗模式和治疗策略有重要的价值。笔者对¹⁸F-FDG PET/CT显像在结核病诊治中主要应用进行综述,以便进一步探索和挖掘其在结核病诊断和治疗中的潜能。

关键词: 结核, 正电子发射断层显像术, 体层摄影术,X线计算机, 诊断显像

Abstract:

Tuberculosis is recognized as a major public health problem in the world. However, in the process of tuberculosis diagnosis and treatment, there are still many problems that are difficult to solve with conventional imaging. The uptake of ¹⁸F-FDG PET/CT is a relatively widely used multimodal imaging, which can simultaneously display both the anatomical and the metabolic information of the lesion. It is helpful in the diagnosis of tuberculosis, especially in the location of concealed tuberculosis lesions, which is superior to conventional imaging. In addition, the metabolism of lesions can reflect the activation of inflammatory cells, and ¹⁸F-FDG PET/CT can provide an objective assessment about the stable state of Mycobacterium tuberculosis and the activity of lesions. During the treatment of tuberculosis, ¹⁸F-FDG PET/CT has better predictive value than conventional imaging in evaluating the early therapeutic effect. ¹⁸F-FDG PET/CT can explore the mechanism of occurrence, development and treatment of tuberculosis from the metabolism perspective, improve the safety and individualization of treatment, and has important value in integrating the medical diagnosis and treatment strategy of tuberculosis. The main application of ¹⁸F-FDG PET/CT imaging in the diagnosis and treatment of tuberculosis was reviewed in order to further explore and tap its potential in the diagnosis and treatment of tuberculosis.

Key words: Tuberculosis, Positron-emission tomography, Tomography,X-ray computed, Diagnostic imaging

中图分类号:

胡玉敬, 边艳珠. ¹⁸F-氟代脱氧葡萄糖正电子发射计算机体层摄影-CT在结核病诊治中的应用价值[J]. 中国防痨杂志, 2023, 45(3): 318-322. doi: 10.19982/j.issn.1000-6621.20220500

Hu Yujing, Bian Yanzhu. Application value of ¹⁸F-FDG PET/CT in diagnosis and treatment of tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(3): 318-322. doi: 10.19982/j.issn.1000-6621.20220500

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¹⁸F-氟代脱氧葡萄糖正电子发射计算机体层摄影-CT在结核病诊治中的应用价值

Application value of ¹⁸F-FDG PET/CT in diagnosis and treatment of tuberculosis

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