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中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (4): 383-389.doi: 10.19982/j.issn.1000-6621.20230399

• 论著 • 上一篇    下一篇


陈瑞麒, 张明五, 王伟, 陈松华, 柳正卫, 陈彬()   

  1. 浙江省疾病预防控制中心结核病预防控制所,杭州 310051
  • 收稿日期:2023-11-05 出版日期:2024-04-10 发布日期:2024-04-01
  • 通信作者: 陈彬
  • 基金资助:

Prevalence and influencing factors of latent tuberculosis infection among elderly rural residents in Changshan County, Zhejiang Province

Chen Ruiqi, Zhang Mingwu, Wang Wei, Chen Songhua, Liu Zhengwei, Chen Bin()   

  1. Department of Tuberculosis Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
  • Received:2023-11-05 Online:2024-04-10 Published:2024-04-01
  • Contact: Chen Bin
  • Supported by:
    National Health Commission-Zhejiang Provincial Health Commission Joint Fund Project(WKJ-ZJ-2118)


目的:了解浙江省常山县农村老年人结核分枝杆菌潜伏感染(latent tuberculosis infection, LTBI)情况及相关影响因素,为制定针对性的干预措施提供科学依据。方法:从“中国疾病预防控制信息系统”的子系统“结核病管理信息系统”中,以2017—2021年近5年结核病报告发病率排序,选取浙江省衢州市常山县报告发病率最高乡镇的3个村庄全部常住农村老年人为调查对象,最终共纳入909名。收集研究对象的人口学特征、吸烟史和饮酒史等信息。采用γ-干扰素诱导蛋白-10 (IP-10) mRNA 释放试验检测LTBI的情况,采用多因素logistic回归分析其影响因素。结果:909名研究对象中,LTBI阳性375例(41.25%),阴性534名(58.75%)。多因素logistic回归分析显示,男性(OR=1.676,95%CI:1.170~2.401)相较于女性,面临更大的LTBI风险,而血清高密度脂蛋白水平较高(OR=0.607,95%CI:0.433~0.852)的人群,其LTBI风险则相对较小。结论:浙江省常山县农村老年人LTBI率较高,特别要关注男性和高密度脂蛋白水平偏低的人群。

关键词: 分枝杆菌,结核, 感染, 因素分析,统计学


Objective: To investigate the status of latent tuberculosis infection (LTBI) among elderly rural residents in Changshan County, Zhejiang Province, and its related influencing factors, so as to provide scientific basis for formulating targeted intervention measures. Methods: In the “Tuberculosis Management Information System”, a subsystem of the “China Disease Control Information System”, the towns were sorted by the reported incidence of tuberculosis in the past five years from 2017 to 2021, all the permanent elderly rural residents were selected as the investigation objects in the three villages with the highest reported incidence in Changshan County, Quzhou City, Zhejiang Province, and a total of 909 people were included. Demographic information, smoking history and drinking history were collected. LTBI was detected by interferon gamma-induced protein 10 (IP-10) mRNA release test, and its influencing factors were analyzed by multivariate logistic regression. Results: Among the 909 study subjects, 375 tested positive for LTBI (41.25%) and 534 tested negative (58.75%). Multivariable logistic regression analysis showed that male participants (OR=1.676,95%CI: 1.170-2.401) had a higher risk of LTBI than female participants, while those with higher levels of serum high-density lipoprotein (OR=0.607,95%CI: 0.433-0.852) had a relatively lower risk of LTBI. Conclusion: Elderly rural residents in Changshan County, Zhejiang Province have a high prevalence of LTBI, with particular attention should be paid to males and those with lower levels of high-density lipoprotein.

Key words: Mycobacterium tuberculosis, Infection, Factor analysis, statistics