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中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (2): 165-172.doi: 10.19982/j.issn.1000-6621.20230395

• 论著 • 上一篇    下一篇


张静1, 付若楠2, 王森路1, 冯建宇3, 张玲1, 古丽娜·巴德尔汗1, 祖力卡提阿衣·阿布都拉1, 王新旗1()   

  1. 1新疆维吾尔自治区疾病预防控制中心结核病与麻风病防治中心, 乌鲁木齐 830002
    2新疆医科大学公共卫生学院, 乌鲁木齐 830011
    3新疆维吾尔自治区阿克苏地区疾病预防控制中心结防科,阿克苏 843000
  • 收稿日期:2023-11-01 出版日期:2024-02-10 发布日期:2024-01-30
  • 通信作者: 王新旗
  • 基金资助:

Analysis of willingness of receiving preventive treatment in patients with latent tuberculosis infection among close contacts of pulmonary tuberculosis in high-burden areas

Zhang Jing1, Fu Ruonan2, Wang Senlu1, Feng Jianyu3, Zhang Ling1, Gulina Badeerhan1, Zulikatiayi Abudula1, Wang Xinqi1()   

  1. 1Tuberculosis and Leprosy Prevention and Control Centre,Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention,Urumqi 830002,China
    2School of Public Health,Xinjiang Medical University,Urumqi 830011,China
    3Aksu Region Center for Disease Control and Prevention,Xinjiang Uygur Autonomous Region,Aksu 843000,China
  • Received:2023-11-01 Online:2024-02-10 Published:2024-01-30
  • Contact: Wang Xinqi
  • Supported by:
    Young Medical Science and Technology Talents Special Scientific Research Project of Health Commission of Xinjiang Uygur Autonomous Region(WJWY-202239);Science and Technology Association Young Talent Lifting Project of Xinjiang Uygur Autonomous Region(RCTJ42);Xinjiang Uygur Autonomous Region Natural Science Foundation Project(2023D01C57)

摘要: 目的: 了解高负担地区肺结核密切接触者中结核分枝杆菌潜伏感染者预防性治疗接受意愿情况及其影响因素,为新疆维吾尔自治区结核分枝杆菌潜伏感染者预防性治疗工作的政策制定提供依据。方法: 采用横断面调查研究,选取2021年8月1日至2022年12月31日新疆维吾尔自治区阿克苏地区阿瓦提县、乌什县确诊的肺结核患者3023例作为指示病例,对指示病例的6407名密切接触者进行结核分枝杆菌潜伏感染筛查,判定结核分枝杆菌潜伏感染者529例,对其进行预防性治疗接受意愿问卷调查,收集人口特征、生活习惯、居住环境、接触信息、健康状况及接受意愿等信息,回收有效问卷516份。以预防性治疗接受意愿为因变量构建binomial-logit链接广义线性模型,分析预防性治疗接受意愿情况的影响因素。结果: 497例愿意接受预防性治疗,接受率为96.32%(497/516)。与指示病例不共同居住的结核分枝杆菌潜伏感染者更容易接受预防性治疗(OR=5.713,95%CI:1.477~22.097),除指示病例外未接触其他结核病患者的结核分枝杆菌潜伏感染者更容易拒绝预防性治疗(OR=0.142,95%CI:0.039~0.516)。结论: 高负担地区肺结核密切接触者的结核分枝杆菌潜伏感染者对预防性治疗的接受意愿较高,其接受意愿受自身经济水平和与肺结核患者接触情况影响。

关键词: 分枝杆菌,结核, 分枝杆菌感染, 问卷调查, 因素分析,统计学

Abstract: Objective: To understand the willingness of accepting tuberculosis preventive treatment (TPT) and its influencing factors among patients with latent tuberculosis infection (LTBI) in tuberculosis high-burden areas of Xinjiang Uygur Autonomous Region and to provide evidence for policy making. Methods: A cross-sectional study was conducted to select 3023 patients with tuberculosis confirmed in Awati County and Wushi County, Aksu Prefecture, Xinjiang Uygur Autonomous Region, from August 1, 2021 to December 31, 2022, as index cases, then 6407 close contacts of index cases were screened for LTBI after which 529 LTBI patients were identified. A questionnaire survey was conducted on the willingness of accepting TPT. Information on population characteristics, daily habits, living environment, contact information, health status was collected too. 516 valid questionnaires were retrieved. A binomial-logit linked generalized linear model was constructed to explore the influencing factors. Results: 497 cases were willing to receive TPT, with an acceptance rate of 96.32% (497/516). Those LTBI patients who do not live together with the indicated case were more likely to receive preventive treatment (OR=5.713,95%CI: 1.477-22.097), and those who do not contact other tuberculosis patients except the indicated case were more likely to refuse preventive treatment (OR=0.142,95%CI: 0.039-0.516). Conclusion: LTBI patients among close contacts in high tuberculosis burden areas have a high willingness to receive TPT, which is influenced by their own economic level and contact with tuberculosis patients.

Key words: Mycobacterium tuberculosis, Mycobacterium Infections, Questionnaires, Factor analysis, statistical