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中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (2): 239-244.doi: 10.19982/j.issn.1000-6621.20230377

• 综述 • 上一篇    下一篇


尚雪恬, 潘丽萍()   

  1. 首都医科大学附属北京胸科医院/耐药结核病研究北京市重点实验室/北京市结核病胸部肿瘤研究所,北京 101149
  • 收稿日期:2023-10-19 出版日期:2024-02-10 发布日期:2024-01-30
  • 通信作者: 潘丽萍
  • 基金资助:

Role of tissue kallikrein family in pathogenesis of microorganism infection

Shang Xuetian, Pan Liping()   

  1. Beijing Chest Hospital, Capital Medical University/Beijing Key Laboratory for Drug Resistant Tuberculosis Research/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  • Received:2023-10-19 Online:2024-02-10 Published:2024-01-30
  • Contact: Pan Liping
  • Supported by:
    National Natural Science Foundation of China(81902024);National Natural Science Foundation of China(82172279);Beijing Natural Science Foundation(7192038);Tongzhou Yunhe Project(YH201807)


组织激肽释放酶(tissue kallikrein-related peptidase, KLK)家族是丝氨酸蛋白酶家族中一种具有胰蛋白酶或胰凝乳蛋白酶性质的蛋白水解酶亚群,有15个家族蛋白,分别为KLK1~KLK15。近年来,越来越多的研究表明,KLK家族可通过切割病毒和细菌关键蛋白、激活多种宿主受体、调控激肽系统等方式参与机体的多种生理活动,影响着病毒、细菌和真菌中多种病原微生物感染的进程,作用机制复杂且广泛。本文通过对近年来KLK家族蛋白在微生物感染中的作用和机制进行综述,以更好地探究KLK在微生物感染中的重要作用,特别是为其在结核分枝杆菌感染中的研究提供思路,也为KLK家族蛋白作为抗结核治疗靶点提供理论基础。

关键词: 病原, 分枝杆菌,结核, 感染, 组织激肽释放酶类, 综述文献(主题)


Tissue kallikrein-related peptidase (KLK) is a subgroup of proteolytic enzymes with trypsin or chymotrypsin properties in the serine protease family, consisting of 15 family proteins, respectively named as KLK1 to KLK15. In recent years, more and more studies have shown that KLK can participate in various physiological activities by cutting key proteins of viruses and bacteria, activating various host receptors, regulating the kinin system, etc., affecting the course of affecting the course of various pathogenic microorganisms infection in viruses, bacteria and fungi, and the mechanism of action is complex and extensive. In this paper, the role and mechanism of KLK family proteins in microbial infection in recent years were reviewed, so as to better explore the important role of KLK in microbial infection, especially to provide ideas for their research in Mycobacterium tuberculosis infection, and to provide a theoretical basis for KLK family proteins to be used as anti-tuberculosis therapeutic targets.

Key words: Noxae, Mycobacterium tuberculosis, Infection, Tissue kallikreins, Review literature as topic