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中国防痨杂志 ›› 2023, Vol. 45 ›› Issue (3): 253-259.doi: 10.19982/j.issn.1000-6621.20220391

• 专题笔谈 • 上一篇    下一篇

结核分枝杆菌潜伏感染与活动性结核病的鉴别诊断

夏辉1, 王瑞白2(), 赵雁林1   

  1. 1中国疾病预防控制中心结核病预防控制中心/国家结核病参比实验室,北京102206
    2中国疾病预防控制中心传染病预防控制所结核病室,北京102206
  • 收稿日期:2022-10-09 出版日期:2023-03-10 发布日期:2023-03-07
  • 通信作者: 王瑞白 E-mail:wangruibai@icdc.cn

Differential diagnosis between latent tuberculosis infection and active tuberculosis

Xia Hui1, Wang Ruibai2(), Zhao Yanlin1   

  1. 1National Tuberculosis Reference Laboratory, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
    2Tuberculosis Department, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
  • Received:2022-10-09 Online:2023-03-10 Published:2023-03-07
  • Contact: Wang Ruibai E-mail:wangruibai@icdc.cn

摘要:

中国是结核病及结核分枝杆菌潜伏感染高负担国家。结核分枝杆菌潜伏感染及活动性结核病的治疗管理和预后完全不同,现有潜伏感染诊断技术并不能有效预测和鉴别活动性结核病的进展和发生。因此,需要探索更加准确的生物标志物。本文主要就结核分枝杆菌潜伏感染和活动性结核病鉴别诊断生物标志物研究进展及问题进行总结和归纳,并展望其发展方向。

关键词: 分枝杆菌,结核, 感染, 生物学标记, 诊断,鉴别, 总结性报告(主题)

Abstract:

China is a country with a high burden of tuberculosis and latent tuberculosis infection. The treatment and prognosis of latent tuberculosis infection and active tuberculosis are completely different. The current available diagnostic tools for tuberculosis infection cannot effectively predict the progress of infection and differentiate it from active tuberculosis, therefore, more accurate biomarkers need to be developed. The research progress, challenges and prospects of biomarkers for differential diagnosis between latent tuberculosis infection and active tuberculosis were reviewed in the present study.

Key words: Mycobacterium tuberculosis, Infection, Biological markers, Diagnosis, differential, Consensus development conferences as topic

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