基于血液样本的转录标识物在结核病诊断中的研究进展

doi:10.19982/j.issn.1000-6621.20230182

摘要/Abstract

摘要：

开发便捷、快速、准确的结核病诊断技术是终止结核病的重要一环。现有检测方法存在痰液样本采集困难等问题,而基于血液样本的转录标识物的检测方法有望弥补这些缺陷。本文综述血液转录标识物在结核病诊断中的研究进展及其应用,探讨其局限性与未来发展方向。

Abstract:

Development of convenient, rapid and accurate tuberculosis (TB) diagnostic assays is an important part of ending TB. Current detection assays have drawbacks such as difficulties in sputum collection, which are expected to be overcome by methods based on blood transcripomic biomarkers. We conducted a review about the progress, limitations, and prospects of blood-based transcripomic biomarkers in the diagnosis of TB.

Key words: Tuberculosis, Diagnosis, Transcription factors, Biological markers

中图分类号:

R52
R852.2

贝呈, 李蒙, 高谦. 基于血液样本的转录标识物在结核病诊断中的研究进展[J]. 中国防痨杂志, 2023, 45(8): 801-807. doi: 10.19982/j.issn.1000-6621.20230182

Bei Cheng, Li Meng, Gao Qian. Research progress on blood transcriptomic biomarkers in the diagnosis of tuberculosis[J]. Chinese Journal of Antituberculosis, 2023, 45(8): 801-807. doi: 10.19982/j.issn.1000-6621.20230182

图/表 1

参考文献 69

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目的	敏感度	特异度
筛选(triage)
最低标准	>90%	>70%
最佳标准	>95%	>80%
确诊(confirmatory)
最低标准	(1)总体敏感度≥65%;(2)涂片与培养均为阳性的患者中敏感度>98%	≥98%
最佳标准	(1)涂片阴性且培养阳性的患者中敏感度≥68%;(2)涂片与培养均为阳性的患者中敏感度>98%	≥98%