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中国防痨杂志 ›› 2003, Vol. 25 ›› Issue (2): 71-74.

• 论著 • 上一篇    下一篇

合并糖尿病肺结核与无糖尿病结核病人的三种抗结核药物药代动力学观察

高微微；段连山；黄学锐；卜建铃；赵伟杰；李惠文；梁桂芳；马玙；   

  1. 北京市结核病胸部肿瘤研究所 北京 101149；
  • 出版日期:2003-02-10 发布日期:2003-11-03

Observation of the pharmacokinetics of three antituberculous drugs in the serum of pulmonary tuberculosis patients with or without diabetes of different age groups

GAO Wei wei,DUAN Lian shan,HUANG Xue rui,et al.   

  1. Beijng Tuberculosis and Thoracic Tumor Reserch Institute,Beijing 101149
  • Online:2003-02-10 Published:2003-11-03

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摘要： 目的　观察肺结核合并糖尿病患者对所用三种抗结核药物INH、RFP和OFLX的药代动力学参数,为临床用药提供理论依据。方法 随机观察17例志愿受试者,观察组9例,为合并糖尿病肺结核。对照组8例,为无糖尿病结核病患者。两组年龄具有统计学差异(P<0.05)。用高压液相色谱法检测两组病人口服INH0.4、RFP0.6和OFLX0.6的药物浓度,其数据用3P87程序进行处理。结果 INH除两组tmax有统计学差异(P<0.05),其它参数t1/2(h)、Cmax(μg/ml)、AUC(μg/(ml·h))均无统计学差异(P>0.05)。RFP两组均无统计学差异(P>0.05)。OFLX两组上述4种参数对比均有统计学差异(P<0.05)。结论 (1)INH、RFP基本上不受患者糖尿病、年龄和性别因素的影响。(2)OFLX其代谢与患者糖尿病或年龄有关,在接近老年病人同时患有糖尿病者,由肾代谢的OFLX应适当选用安全治疗量内偏低剂量更合适,已防蓄积出现其他毒副反应。

关键词: 结核,肺, 糖尿病, 抗结核药, 药代动力学

Abstract: Objective To observe the pharmacokinetics of INH,RFP and OFLX in the serum of pulmonary tuberculosis patients with diabetes to provide references in choosing clinical therapeutic regimens.Methods 17 adult tuberculosis patients were randomly divided into two groups.The observe group,9 cases (pulmonary tuberculosis patients with diabetes);the control group,8 cases (non diabetes tuberculosis patients).They took INH 0.4,RFP 0.6,OFLX 0.6 orally.The concentrations of the three antituberculous drugs in the serum were measured by HPLC (high performance liquid chromatography).The data were calculated with software 3p87.Results There was significant difference in the T max of INH only ( P< 0.05).There was no significant difference between the two groups in the other pharmacokinetic parametres such as t 1/2 (h),C max (μg/ml),AUC(μg/(ml·h)) of INH ( P> 0.05).There was no significant difference between the two groups in the t 1/2 (h),t max (h),C max (μg/ml),AUC(μg/ml· 1) of RFP( P > 0.05). There were significant differences between the two groups in the t 1/2 (h),T max (h),C max (μg/ml),AUC(μg/(ml·h)) of OFLX.Conclusion 1.INH and RFP,were not affected by the factors of diabetes,age and sex.2.OFLX,was affected by the factors of diabetes or age.

Key words: Tuberculosis,pulmonary, Diabetes mellitus, Antitubercular agents, Pharmacokinetics

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