关键词: 结核,肺, 结核,抗多种药物性, 糖尿病, 共病现象, 体层摄影术,X线计算机, 疾病特征

Abstract:

Objective To compare the CT findings of pulmonary multi-drug-resistant tuberculosis with or without diabetic. Methods Data of 660 pulmonary multi-drug-resistant tuberculosis patients were collected. All the patients were from Beijing Chest Hospital affiliated to Capital Medical University between 2012 and 2017 and diagnosed on sputum-positive and results of drug sensitivity test. They were divided into diabetic group (n=159) and non-diabetic group (n=501). A total of 120 patients were randomly selected from the two groups (each n=60), and the signs and distribution in CT images of them were re-diagnosed by two radiologists without information of complications. Data were ananlyzed using SPSS 17.0 software by chi-square test or Fisher exact test. Quantitative data were analyzed by Mann-Whitney U test. P<0.05 was considered statistically significant. Results The segmental or lobar consolidation, large nodules, cavities and pleural effusion in diabetic group were significantly higher than those in non-daibetic group (48.3% (29/60) vs. 28.3% (17/60), χ ²=5.08, P=0.024; 26.7% (16/60) vs. 11.7% (7/60), χ ²=4.36, P=0.037; 93.3% (56/60) vs. 76.7% (46/60), χ ²=6.54, P=0.011; 40.0% (24/60) vs. 20.0% (12/60), χ ²=5.71, P=0.017), so were the number of lobes involved by segmental or lobar consolidation, large nodules and the number of lobes involved by any form of cavities (0.78±0.96 vs. 0.38±0.72, U=1380.50, P=0.011; 0.48±0.96 vs. 0.13±0.39, U=1511.00, P=0.027; 2.05±1.43 vs. 1.58±1.43, U=1432.00, P=0.046); while bronchiectasis in diabetic group was significantly lower than that in non-daibetic group (45.0% (27/60) vs. 70.0% (42/60), χ ²=7.67, P=0.006; 0.97±1.37 vs. 1.58±1.57, U=1335.50, P=0.010). Conclusion The frequency and range of segment or lager consolidation segmental or lobar consolidation, large nodules and cavity, as well as pleural effusion, are higher in patients of pulmonary multi-drug-resistant tuberculosis complicated with diabetic, while the bronchiectasis is more frequent in patients without diabetes mellitus.

Key words: Tuberculosis,pulmonary, Tuberculosis,multidrug-resistant, Diabetes mellitus, Comorbidity, Tomography,X-ray computed, Disease attributes