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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (11): 1122-1125.doi: 10.19982/j.issn.1000-6621.20220330

• 标准解读 • 上一篇    下一篇

《世界卫生组织结核病整合指南模块4:药物敏感结核病的治疗》解读

袁媛1, 卢水华2()   

  1. 1复旦大学附属公共卫生临床中心,上海 201508
    2南方科技大学附属第二医院/深圳市第三人民医院/国家感染性疾病临床研究中心,深圳 518112
  • 收稿日期:2022-08-29 出版日期:2022-11-10 发布日期:2022-11-03
  • 通信作者: 卢水华 E-mail:lushuihua66@126.com
  • 基金资助:
    广东省感染性疾病<结核病>临床医学研究中心(2020B1111170014);深圳市结核病临床医学研究中心(深科技创新〔2021〕287号)

Interpretation of WHO consolidated guidelines on tuberculosis Module 4: Treatment of drug-susceptible tuberculosis

Yuan Yuan1, Lu Shuihua2()   

  1. 1Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
    2National Clinical Research Center for Infectious Diseases/The Third People’s Hospital of Shenzhen/The Second Affiliated Hospital of Southern University of Science and Technology, Guangdong Province, Shenzhen 518112, China
  • Received:2022-08-29 Online:2022-11-10 Published:2022-11-03
  • Contact: Lu Shuihua E-mail:lushuihua66@126.com
  • Supported by:
    Guangdong Clinical Research Center for Infectious Diseases (Tuberculosis)(2020B1111170014);Shenzhen Tuberculosis Clinical Medical Research Center (Shenzhen Science and Technology Innovation [2021]287)

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摘要：

世界卫生组织(World Health Organization,WHO)于2010年发布了治疗药物敏感结核病(drug susceptible tuberculosis,DS-TB)的建议方案。这一方案广泛应用,但是在临床实际应用中发现部分患者因治疗时间较长未能完成6个月的治疗方案。基于两项Ⅲ期临床试验,WHO发布的2022年版指南首次增加了2021年最近一轮指南制定小组给出的相关循证建议,即推荐疗程4个月的方案治疗DS-TB。本文中,笔者就最新发布的2022年版指南对DS-TB的治疗方案进行解读,并提出展望。

关键词: 结核, 肺, 治疗应用, 总结性报告(主题)

Abstract:

In 2010, World Health Organization (WHO) issued recommendations for the treatment of drug susceptible tuberculosis (DS-TB). This treatment regimen is widely used, but in clinical practice, it is found that many patients fail to complete the 6-month treatment due to the long treatment time. Based on two phase Ⅲ trials, for the first time, the 2022 WHO guidelines add to the evidence-based recommendations of the most recent 2021 guideline development panel, which recommended a 4-month regimen for DS-TB. In this article, the author interprets the treatment of DS-TB according to the latest 2022 guidelines.

Key words: Tuberculosis, pulmonary, Therapeutic uses, Consensus development conferences as topic

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