Email Alert | RSS    帮助

中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (7): 732-737.doi: 10.19982/j.issn.1000-6621.20220036

• 综述 • 上一篇    下一篇

纳米药物递送系统在结核病治疗中的研究进展

田娜, 褚洪迁, 孙照刚()   

  1. 首都医科大学附属北京胸科医院转化医学研究室/北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室,北京 101149
  • 收稿日期:2022-02-18 出版日期:2022-07-10 发布日期:2022-07-06
  • 通信作者: 孙照刚 E-mail:sunzg75@163.com
  • 基金资助:
    北京市自然科学基金委-北京市教委联合资助重点项目(KZ202110025034);国家自然科学基金(82001946);北京市自然科学基金(7214300)

Recent progress of Nano-drug delivery system for tuberculosis treatment

TIAN Na, CHU Hong-qian, SUN Zhao-gang()   

  1. Translational Medicine Center, Beijing Chest Hospital, Capital Medical University/Beijing Key Laboratory in Drug Resistant Tuberculosis Research/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  • Received:2022-02-18 Online:2022-07-10 Published:2022-07-06
  • Contact: SUN Zhao-gang E-mail:sunzg75@163.com
  • Supported by:
    Key Project Jointly Funded by Beijing Municipal Natural Science Foundation of China and Beijing Municipal Education Commission(KZ202110025034);National Natural Science Foundation of China(82001946);Beijing Natural Science Foundation(7214300)

摘要:

目前,结核病防治形势仍十分严峻。然而,传统抗结核药物治疗方案存在疗程长、药物不良反应多以及患者依从性差等问题,常导致治疗失败,故亟需可以控制结核病的新药或新剂型。装载抗结核药物的纳米药物递送系统可以将抗结核药物主动或被动靶向到被感染的细胞或病灶部位内,杀菌的同时,还具有缓释给药、减少给药频率、减少剂量依赖性不良反应等优势。本文综述了纳米递药系统在结核病治疗方面的应用情况及前景。

关键词: 结核, 纳米技术, 治疗应用, 综述

Abstract:

At present, the prevention and control of tuberculosis are still severe. However, the conventional anti-tuberculosis drug regimens have several limitations such as a long course of treatment, high incidence of adverse reactions, and poor patient compliance, which often lead to treatment failures. Therefore, there is an urgent need for new drugs or new dosage forms that can control tuberculosis. The nano-drug delivery system loaded with anti-tuberculosis drugs can actively or passively deliver drugs into infected macrophages or focal sites for sterilization, and it also have advantages of sustained-release administration, reducing dosing frequency and dose-dependent adverse reactions. etc. This article reviews the application and prospect of nano-drug delivery systems in the treatment of tuberculosis.

Key words: Tuberculosis, Nanotechnology, Therapeutic uses, Review

中图分类号: