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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (7): 732-737.doi: 10.19982/j.issn.1000-6621.20220036

• 综述 • 上一篇    下一篇


田娜, 褚洪迁, 孙照刚()   

  1. 首都医科大学附属北京胸科医院转化医学研究室/北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室,北京 101149
  • 收稿日期:2022-02-18 出版日期:2022-07-10 发布日期:2022-07-06
  • 通信作者: 孙照刚
  • 基金资助:

Recent progress of Nano-drug delivery system for tuberculosis treatment

TIAN Na, CHU Hong-qian, SUN Zhao-gang()   

  1. Translational Medicine Center, Beijing Chest Hospital, Capital Medical University/Beijing Key Laboratory in Drug Resistant Tuberculosis Research/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  • Received:2022-02-18 Online:2022-07-10 Published:2022-07-06
  • Contact: SUN Zhao-gang
  • Supported by:
    Key Project Jointly Funded by Beijing Municipal Natural Science Foundation of China and Beijing Municipal Education Commission(KZ202110025034);National Natural Science Foundation of China(82001946);Beijing Natural Science Foundation(7214300)



关键词: 结核, 纳米技术, 治疗应用, 综述


At present, the prevention and control of tuberculosis are still severe. However, the conventional anti-tuberculosis drug regimens have several limitations such as a long course of treatment, high incidence of adverse reactions, and poor patient compliance, which often lead to treatment failures. Therefore, there is an urgent need for new drugs or new dosage forms that can control tuberculosis. The nano-drug delivery system loaded with anti-tuberculosis drugs can actively or passively deliver drugs into infected macrophages or focal sites for sterilization, and it also have advantages of sustained-release administration, reducing dosing frequency and dose-dependent adverse reactions. etc. This article reviews the application and prospect of nano-drug delivery systems in the treatment of tuberculosis.

Key words: Tuberculosis, Nanotechnology, Therapeutic uses, Review