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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (2): 120-124.doi: 10.19982/j.issn.1000-6621.20210558

• 专题笔谈 • 上一篇    下一篇

重视结核分枝杆菌抗原检测技术研发

孙照刚()   

  1. 首都医科大学附属北京胸科医院转化医学研究室/北京市结核病胸部肿瘤研究所耐药结核病研究北京市重点实验室,北京 101149
  • 收稿日期:2021-08-18 出版日期:2022-02-10 发布日期:2022-02-14
  • 通信作者: 孙照刚 E-mail:sunzg75@163.com
  • 基金资助:
    北京市自然科学基金委-北京市教委联合资助重点项目(21JG0034)

Attention should be paid to the research and development of Mycobacterium tuberculosis antigen detection technology

SUN Zhao-gang()   

  1. Translational Medicine Center, Beijing Chest Hospital, Capital Medical University/Beijing Key Laboratory in Drug Resistant Tuberculosis Research/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  • Received:2021-08-18 Online:2022-02-10 Published:2022-02-14
  • Contact: SUN Zhao-gang E-mail:sunzg75@163.com
  • Supported by:
    Key Project Jointly Funded by Beijing Municipal Natural Science Foundation of China and Beijing Municipal Education Commission(21JG0034)

摘要:

结核病疫情防控面临的新形势需要考虑新的快速、便捷的早期筛查或诊断技术。简便、快速和廉价的免疫学诊断技术是结核病研究人员重点关注并且坚持不懈的努力方向。目前结核分枝杆菌抗原靶标包括单一抗原的检测和多种抗原同时检测,涉及的检测技术包括免疫学技术、质谱技术及纳米技术。随着技术的进步,结核分枝杆菌抗原在检测技术和研究思路上都取得了较大的进展,但仍存在一些问题。结核分枝杆菌抗原研发的方向应注重多种特异性抗原同时检测。随着新型纳米材料和传感方法的发展,特异性强、免疫原性好的抗原得到不断发现和深入研究,这将有助于结核分枝杆菌抗原检测得到新的完善和发展。

关键词: 分枝杆菌,结核, 抗原, 诊断技术和方法, 总结性报告(主题)

Abstract:

New fast and convenient early screening or diagnosis technologies are required because of new situation of tuberculosis epidemic prevention and control. Simple, fast and cheap immunological diagnosis technology is the focus and persistent efforts of tuberculosis researchers. At present, the antigen targets of Mycobacterium tuberculosis (MTB) include the detection of single antigen and the simultaneous detection of multiple antigens. The involved detection technologies include immunological technology, mass spectrometry technology and nanotechnology. With the development of technology, great progress has been made in detection technology and research ideas of MTB antigen. However, there are still some problems. The simultaneous detection of multiple specific antigens should be deeply developed in research of MTB antigen. The development of new nanomaterials and sensing methods, as well as the discovery and research of antigens with strong specificity and good immunogenicity, are help to get new improvement and development of MTB antigen detection method.

Key words: Mycobacterium tuberculosis, Antigens, Diagnostic techniques and procedures, Consensus development conferences as topic

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