宏基因组测序应用于结核病防治的研究进展

doi:10.19982/j.issn.1000-6621.20240111

中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (8): 976-981.doi: 10.19982/j.issn.1000-6621.20240111

宏基因组测序应用于结核病防治的研究进展

王怡婷¹, 孟祥莉², 付茵¹, 曹晓龙³, 郑惠文⁴, 贺文从⁵, 宋泽萱³, 赵雁林³()

¹北京市疾病预防控制中心免疫预防所,北京 100013
²宁波国际旅行卫生保健中心(宁波海关口岸门诊部),宁波 315012
³中国疾病预防控制中心国家结核病参比实验室,北京 102206
⁴国家儿童医学中心,国家呼吸系统疾病临床医学研究中心,教育部儿科重大疾病研究重点实验室,首都医科大学附属北京儿童医院北京市儿科研究所,儿童呼吸道感染性疾病研究北京市重点实验室呼吸疾病研究室,北京 100045
⁵首都医科大学附属北京同仁医院检验科,北京 100730

收稿日期:2024-03-27 出版日期:2024-08-10 发布日期:2024-08-01
通信作者: 赵雁林 E-mail:zhaoyl@chinacdc.cn
基金资助:
国家重点研发计划(2022YFC2305200);宁波市自然科学基金(2018A610238);北京市自然科学基金(7224328)

Advances in the application of metagenomic sequencing for tuberculosis prevention and control

Wang Yiting¹, Meng Xiangli², Fu Yin¹, Cao Xiaolong³, Zheng Huiwen⁴, He Wencong⁵, Song Zexuan³, Zhao Yanlin³()

¹Institution for Immunization and Prevention,Beijing Center for Disease Prevention and Control, Beijing 100013,China
²Ningbo International Travel Healthcare Center, Ningbo Customs District, Ningbo 315012,China
³National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing 102206,China
⁴Laboratory of Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Center for Children’s Health, Beijing 100045,China
⁵Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730,China

Received:2024-03-27 Online:2024-08-10 Published:2024-08-01
Contact: Zhao Yanlin E-mail:zhaoyl@chinacdc.cn
Supported by:
National Key Research and Development Program of China(2022YFC2305200);Ningbo Natural Science Foundation(2018A610238);Beijing Natural Science Foundation(7224328)

摘要/Abstract

摘要：

结核病诊断技术一直是控制结核病疫情的关键,但传统诊断方法敏感度低且耗时长,难以满足临床对诊断效率的高要求。随着测序技术和生物信息学的高速发展,宏基因组测序技术在近几年内逐渐应用于多种传染性疾病的诊断中。笔者对宏基因组测序技术在结核病防治中的应用情况加以阐述,并讨论其未来在结核病诊断中的应用前景。

关键词: 结核, 分子诊断技术, 综述

Abstract:

Effective diagnosis is crucial for controlling tuberculosis outbreaks, yet conventional diagnostic approaches lack sensitivity and are notably time-consuming, failing to satisfy the demands for high-efficiency clinical diagnostics. With the advent of advanced sequencing technologies and bioinformatics, metagenomic sequencing has increasingly been recognized for its utility in the diagnosis of a broad spectrum of infectious diseases. This study explores the application of metagenomic sequencing in the management and diagnosis of tuberculosis, emphasizing its transformative potential for future enhancements in the prevention of tuberculosis.

Key words: Tuberculosis, Molecular diagnostic techniques, Review

中图分类号:

王怡婷, 孟祥莉, 付茵, 曹晓龙, 郑惠文, 贺文从, 宋泽萱, 赵雁林. 宏基因组测序应用于结核病防治的研究进展[J]. 中国防痨杂志, 2024, 46(8): 976-981. doi: 10.19982/j.issn.1000-6621.20240111

Wang Yiting, Meng Xiangli, Fu Yin, Cao Xiaolong, Zheng Huiwen, He Wencong, Song Zexuan, Zhao Yanlin. Advances in the application of metagenomic sequencing for tuberculosis prevention and control[J]. Chinese Journal of Antituberculosis, 2024, 46(8): 976-981. doi: 10.19982/j.issn.1000-6621.20240111

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宏基因组测序应用于结核病防治的研究进展

Advances in the application of metagenomic sequencing for tuberculosis prevention and control

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