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中国防痨杂志 ›› 2025, Vol. 47 ›› Issue (8): 976-980.doi: 10.19982/j.issn.1000-6621.20250124

• 专题笔谈 • 上一篇    下一篇

基于舌拭子的结核分枝杆菌复合群核酸检测方法在肺结核诊断和筛查中的应用前景与挑战

夏辉, 赵雁林()   

  1. 中国疾病预防控制中心结核病预防控制中心;传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心,北京102206
  • 收稿日期:2025-03-28 出版日期:2025-08-10 发布日期:2025-08-01
  • 通信作者: 赵雁林,Email: zhaoyl@chinacdc.cn
  • 基金资助:
    结核病预防与控制项目(2528);公卫人才培养支持项目(01056)

The potentials and challenges of using tongue swab for Mycobacterium tuberculosis complex detection through nucleic acid amplification tests in the diagnosis and screening of pulmonary tuberculosis

Xia Hui, Zhao Yanlin()   

  1. National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Center for Disease Control and Prevention,Beijing 102206, China
  • Received:2025-03-28 Online:2025-08-10 Published:2025-08-01
  • Contact: Zhao Yanlin, Email: zhaoyl@chinacdc.cn
  • Supported by:
    Program for Tuberculosis Prevention and Control(2528);Public Health Personal Development Support Project(01056)

摘要:

结核病仍然是全球面临的重大公共卫生问题。病原学检查是诊断结核病的重要手段,然而,部分疑似肺结核患者早期无痰或者难以获取合格痰标本,导致基于痰标本检测的实验室手段不能充分发挥作用。与此同时,基于口腔拭子、血液、尿液和体液等非痰标本的检查方法已成为结核病实验室诊断研发的热点。笔者就舌拭子在结核病诊断与筛查中的研究现状、存在的问题和挑战,以及需要关注的问题等进行系统分析,以期为相关技术优化、多场景应用试点等提供参考。

关键词: 结核,肺, 诊断, 舌拭子, 总结性报告

Abstract:

Tuberculosis (TB) remains a major global public health challenge. Etiological examination serves as a critical approach for TB diagnosis. However, some suspected pulmonary TB patients initially present with no sputum or face difficulties in providing qualified sputum specimens, limiting the effectiveness of sputum-based laboratory detection methods. Concurrently, non-sputum based diagnostic methods, such as oral swab, blood, urine, and other body fluids, has become a focus in TB diagnostic research and development. This article systematically analyzes the current research progress on tongue swab-based TB diagnosis and screening, existing challenges, and key considerations in the application of tongue swabs for TB diagnosis and screening. The aim is to provide references for technological optimization and pilot implementations across diverse scenarios.

Key words: Tuberculosis, pulmonary, Diagnosis, Tongue swab, Consensus development conference

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