结核病短程治疗研究:回顾与展望

doi:10.19982/j.issn.1000-6621.20240219

中国防痨杂志 ›› 2024, Vol. 46 ›› Issue (9): 991-997.doi: 10.19982/j.issn.1000-6621.20240219

结核病短程治疗研究:回顾与展望

李杨¹^,², 孙峰¹^,², 张文宏¹^,²()

¹国家传染病医学中心/复旦大学附属华山医院,上海 200040
²上海市传染病与生物安全应急响应重点实验室/上海市感染与免疫科技创新中心,上海 200040

收稿日期:2024-05-30 出版日期:2024-09-10 发布日期:2024-08-30
通信作者: 张文宏,Email:wenhongzhang@fudan.edu.cn
基金资助:
上海申康医院发展中心临床三年行动计划资助(SHDC2020CR1011B);上海市加强公共卫生体系建设三年行动计划(2020—2022年)(GWV-3.1);国家自然科学基金青年基金(82102406);上海申康医院发展中心模拟RCT项目(SHDC2024CRI047);上海市科技重大专项(HS2021SHZX001)

Short-course treatment for tuberculosis: past achievements and future directions

Li Yang¹^,², Sun Feng¹^,², Zhang Wenhong¹^,²()

¹National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China
²Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Shanghai Sci-Tech Inno Center for Infection and Immunity, Shanghai 200040, China

Received:2024-05-30 Online:2024-09-10 Published:2024-08-30
Contact: Zhang Wenhong, Email: wenhongzhang@fudan.edu.cn
Supported by:
Clinical Research Plan of SHDC(SHDC2020CR1011B);The Three-year (2020—2022) Action Plan Project for Public Health from Shanghai Municipal Health Commission(GWV-3.1);National Natural Science Foundation of China(82102406);RCT Duplicate program of SHDC(SHDC2024CRI047);Shanghai Municipal Science and Technology Major Project(HS2021SHZX001)

摘要/Abstract

摘要：

目前,结核病疫情下降速度缓慢,距离世界卫生组织“终止结核病策略”所设定的里程碑目标仍有较大差距,研发并应用有效的短程治疗方案变得至关重要。本文旨在回顾过去几十年中结核病短程治疗的发展历程,评估当前治疗方法的有效性,以期为未来结核病短程治疗策略的优化提供依据和参考。通过系统性回顾文献和最新的临床试验数据,笔者分析了多种短程治疗方案的疗效、安全性,以及应用场景;并分析、归纳目前短程治疗的主要策略。尽管存在挑战,但通过新型药物的开发、药物剂量优化和更精准的患者评估,结核病的短程治疗有望在未来几年内取得显著进展。

关键词: 结核, 临床方案, 治疗应用, 总结性报告(主题)

Abstract:

The global decline in tuberculosis (TB) incidence has been disappointingly slow, significantly lagging behind the milestones set by the World Health Organization’s End TB Strategy. Consequently, the development and implementation of effective short-course treatment regimens have become imperative. This review aims to examine the progress of short-course TB treatments over the past few decades and evaluate the efficacy of current therapeutic approaches, providing essential references and support for optimizing future treatment strategies. Through a systematic review of the literature and the latest clinical trial data, we analyzed the efficacy, safety, and application scenarios of various short-course treatment regimens. Furthermore, we summarized the main strategies for current short-course treatments. Despite existing challenges, significant progress in tuberculosis short-course treatment is anticipated in the coming years, driven by the development of novel drugs, dose optimization, and more precise patient evaluation.

Key words: Tuberculosis, Clinical protocols, Therapeutic uses, Consensus reports

中图分类号:

R52
R825.2

李杨, 孙峰, 张文宏. 结核病短程治疗研究:回顾与展望[J]. 中国防痨杂志, 2024, 46(9): 991-997. doi: 10.19982/j.issn.1000-6621.20240219

Li Yang, Sun Feng, Zhang Wenhong. Short-course treatment for tuberculosis: past achievements and future directions[J]. Chinese Journal of Antituberculosis, 2024, 46(9): 991-997. doi: 10.19982/j.issn.1000-6621.20240219

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结核病短程治疗研究:回顾与展望

Short-course treatment for tuberculosis: past achievements and future directions

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