脑脊液检测在结核性脑膜炎早期诊断中的研究进展

doi:10.3969/j.issn.1000-6621.2019.01.019

摘要/Abstract

摘要：

结核性脑膜炎(tuberculous meningitis,TBM)是肺外结核中最严重的临床表现类型,具有较高的病死率及致残率,故早期、快速诊断及鉴别诊断TBM对疾病的治疗和预后至关重要。笔者通过综述近年来脑脊液(cerebrospinal fluid,CSF)检测在TBM早期诊断及与化脓性脑膜炎、病毒性脑膜炎(viral meningitis,VM)和新型隐球菌性脑膜炎(cryptococcul neoformans meningitis,CNM)的鉴别诊断方法,旨在为TBM的早期诊断与鉴别诊断提供一定的诊疗思路。

关键词: 结核, 脑膜, 脑脊髓液, 早期诊断, 诊断, 鉴别, 实验室技术和方法, 综述

Abstract:

Tuberculous meningitis (TBM) is the most serious type of extra-pulmonary tuberculosis, which usually causes higher mortality and disability rate. So early and rapid diagnosis of TBM, as well as differential diagnosis with other diseases are crucial for TBM treatment and its prognosis. In this paper, we did a systemically review on the research progress of cerebrospinal fluid testing application in early diagnosis of TBM and in differential diagnosis with pyogenic meningitis, viral meningitis (VM) and cryptococcul neoformans meningitis (CNM) in recent years, aiming to provide some ideas or references for the early diagnosis and differential diagnosis of TBM.

Key words: Tuberculosis, meningeal, Cerebrospinal fluid, Early diagnosis, Diagnosis, differential, Laboratory techniques and methods, Review

王赛赛,马艳,刘洋. 脑脊液检测在结核性脑膜炎早期诊断中的研究进展[J]. 中国防痨杂志, 2019, 41(1): 95-101. doi: 10.3969/j.issn.1000-6621.2019.01.019

Sai-sai WANG,Yan MA,Yang LIU. Research progress on cerebrospinal fluid examinations in early diagnosis of tuberculous meningitis[J]. Chinese Journal of Antituberculosis, 2019, 41(1): 95-101. doi: 10.3969/j.issn.1000-6621.2019.01.019

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