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中国防痨杂志 ›› 2009, Vol. 31 ›› Issue (8): 481-483.

• 论著 • 上一篇    下一篇

非结核分枝杆菌病50例临床分析

吴晓光;高孟秋;马丽萍   

  1. 北京胸科医院 北京 101149
  • 出版日期:2009-08-10 发布日期:2011-11-03

Clinical analysis on 50 cases with Nontuberculous Mycobacteria disease

Wu Xiaoguang,Gao Mengqiu,Ma Liping   

  1. Beijing Chest Hospital,Beijing101149,China
  • Online:2009-08-10 Published:2011-11-03

摘要: 目的探讨非结核分枝杆菌病的临床特点和提高非结核分枝杆菌病的诊断和治疗水平。方法1999年8月—2006年3月间在北京胸科医院住院治疗的患者,痰培养分枝杆菌阳性、菌种鉴定为非结核分枝杆菌的50例患者,进行耐药试验并对其临床表现及治疗效果进行总结。结果非结核分枝杆菌肺病患者对一线抗结核药物均有不同程度的耐药,其中对异烟肼(H)、链霉素(S)耐药率最高,对丁胺卡那霉素(Am)、卡那霉素(Km)耐药率较低。结论非结核分枝杆菌肺病确诊靠菌种鉴定,早期给予合理的化疗方案可取得一定的效果。

关键词: 分枝杆菌感染, 分枝杆菌属, 抗药性, 细菌

Abstract: ObjectiveTo study clinical features and improve level of diagnosis and treatment for nontuberculous mycobacteria(NTM) lung disease. Methods50 patients with NTM lung disease confirmed by culture with Lowestein-Jensen,medium in our hospital between August 1999 and March 2006 were carried out drug susceptibility test, and their clinical manifestation and therapeutic effects were analized.Results The strains isolated from patients with NTM lung disease were resistant to the first line anti-tuberculosis drugs in various degree with highest resistant rate to isoniazid(H) and streptomycin(S) and lower rate to Amikacin(Ak) and Kanamycin(Km).ConclusionsNTM lung diseaseshould be conformed by positive culture and strain identification. Early reasonable chemotherapy may offer satisfied efficacy.

Key words: Mycobacterium infections, Mycobacterium, Drug resistance,bacterial