中国防痨杂志 ›› 2021, Vol. 43 ›› Issue (3): 285-290.doi: 10.3969/j.issn.1000-6621.2021.03.016
收稿日期:
2020-11-10
出版日期:
2021-03-10
发布日期:
2021-03-03
通信作者:
杨松,唐神结
E-mail:yangsong5@aliyun.com;tangsj1106@vip.sina.com
基金资助:
WANG Le-le, YANG Song(), TANG Shen-jie()
Received:
2020-11-10
Online:
2021-03-10
Published:
2021-03-03
Contact:
YANG Song,TANG Shen-jie
E-mail:yangsong5@aliyun.com;tangsj1106@vip.sina.com
摘要:
治疗性药物监测(therapeutic drug monitoring,TDM)是应用血液、尿液或唾液中的药品浓度确定药品剂量,为患者制定治疗方案,以获得最佳疗效,减少耐药及不良反应的检测技术。TDM是个体化治疗的重要策略,可为临床调整药品剂量提供参考。结核病患者血药浓度个体差异大、不良反应多,常导致治疗失败、复发和耐药。目前在结核病治疗中TDM尚未实现标准化,也无任何官方指南。但最近国外的指南推荐对有药品暴露改变风险或预后不良的结核病患者,在治疗期间应行TDM。因此,作者分别就TDM的定义及临床意义、检测技术方法、抗结核药品治疗应用情况作一综述,为临床医师提供参考。
王乐乐, 杨松, 唐神结. 治疗性药物监测在结核病治疗中的应用进展[J]. 中国防痨杂志, 2021, 43(3): 285-290. doi: 10.3969/j.issn.1000-6621.2021.03.016
WANG Le-le, YANG Song, TANG Shen-jie. A review of application of therapeutic drug monitoring in tuberculosis treatment[J]. Chinese Journal of Antituberculosis, 2021, 43(3): 285-290. doi: 10.3969/j.issn.1000-6621.2021.03.016
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