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中国防痨杂志 ›› 2021, Vol. 43 ›› Issue (7): 724-728.doi: 10.3969/j.issn.1000-6621.2021.07.014

• 综述 • 上一篇    下一篇


姚蓉, 陆宇()   

  1. 101149 首都医科大学附属北京胸科医院 耐药结核病研究北京市重点实验室 北京市结核病胸部肿瘤研究所药物研究室
  • 收稿日期:2021-04-05 出版日期:2021-07-10 发布日期:2021-07-09
  • 通信作者: 陆宇
  • 基金资助:

Research and progress of early bactericidal activity of anti-tuberculosis drugs

YAO Rong, LU Yu()   

  1. Beijing Chest Hospital, Capital Medical University, Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Department of Pharmacology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
  • Received:2021-04-05 Online:2021-07-10 Published:2021-07-09
  • Contact: LU Yu



关键词: 抗结核药, 分枝杆菌, 结核, 早期杀菌活性, 药物评价, 综述文献(主题)


The early bactericidal activity of anti-tuberculosis drugs reflects the ability to kill Mycobacterium tuberculosis (MTB) with high metabolism and proliferation after entering the blood and tissues, to control the disease early and reduce the infectivity. Decurrently, commonly used methods for determining early bactericidal activity of drugs mainly include sputum colony forming units on solid medium and determining positive time on liquid medium. The results of the two methods are normally consistent. Early bactericidal activity research is currently an important part of the development of new anti-tuberculosis drugs, which can predict the bactericidal activity of the drug. However, it cannot measure the sterilization activity of the drug, which could only be estimated according to either the recurrence rate after routine clinical trials or the sputum conversion rate in 2 months. At present, the epidemic of tuberculosis is severe, and difficulties and challenges are found in the treatment. It is new drugs with high bactericidal activity are urgently to develop to actively inhibit the growth of MTB and the spread of tuberculosis. This review of the early bactericidal activity of the main anti-tuberculosis drugs and the main research methods aimed to provide reference for the better application of existing drugs and development of new drugs.

Key words: Antitubercular agents, Mycobacterium tuberculosis, Early bactericidal activity, Drug evaluation, Review literature as topic