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中国防痨杂志 ›› 2021, Vol. 43 ›› Issue (7): 729-734.doi: 10.3969/j.issn.1000-6621.2021.07.015

• 综述 • 上一篇    下一篇

非结核分枝杆菌肺病治疗药物研发的现状与挑战

郑璐瑶*, 陆宇(), 陈效友()   

  1. 101149 首都医科大学附属北京胸科医院 耐药结核病研究北京市重点实验室 北京市结核病胸部肿瘤研究所药物研究室(郑璐瑶、陆宇);首都医科大学附属北京地坛医院(陈效友)
  • 收稿日期:2021-04-02 出版日期:2021-07-10 发布日期:2021-07-09
  • 通信作者: 郑璐瑶,陆宇,陈效友 E-mail:luyu4876@hotmail.com;chenxy1998@hotmail.com
  • 基金资助:
    “十三五”国家科技重大专项(2019ZX09721001-007-003);北京市医院管理中心临床医学发展专项(ZYLX202123)

Research and development/exploitation of therapeutic drugs for NTM pulmonary disease:present situation and challenges

ZHENG Lu-yao*, LU Yu(), CHEN Xiao-you()   

  1. *Beijing Key Laboratory of Drug Resistance Tuberculosis Research,Department of Pharmacology,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing Chest Hospital,Capital Medical University,Beijing 101149,China
  • Received:2021-04-02 Online:2021-07-10 Published:2021-07-09
  • Contact: ZHENG Lu-yao,LU Yu,CHEN Xiao-you E-mail:luyu4876@hotmail.com;chenxy1998@hotmail.com

摘要:

非结核分枝杆菌(NTM)隶属于分枝杆菌属,与结核分枝杆菌是“近亲”。近年来,由NTM引起的慢性肺部疾病的患病率正在以惊人的速度增长,甚至在一些国家已经超过了结核病。目前临床上的治疗方案主要为长疗程、联合用药,然而结果往往不尽如人意。迫切需要新的、更有效的药物和化疗方案。作者综述了NTM肺病治疗药物开发的现状与面临的挑战,以期为NTM肺病的治疗提供新的思路。

关键词: 分枝杆菌感染, 非典型性, 抗结核药, 综述文献(主题)

Abstract:

Non-tuberculous mycobacteria (NTM) belongs to the genus mycobacterium,which is “close relative” to Mycobacterium tuberculosis. In recent years, the prevalence of chronic lung diseases caused by NTM is increasing at an alarming rate, even exceeding Mycobacterium tuberculosis in some countries. At present, the clinical treatment mainly relies on long-term therapy with combined medication, but the results are often unsatisfactory. Therefore, there is an urgent need for noval and more effective antimicrobials as well as new chemotherapy regimen. This article reviews the current situation and challenges in NTM drug development, in order to provide new insight for the treatment of NTM pulmonary disease.

Key words: Mycobacterium infections, atypical, Antitubercular agents, Review literature as topic