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中国防痨杂志 ›› 2021, Vol. 43 ›› Issue (7): 645-648.doi: 10.3969/j.issn.1000-6621.2021.07.001

• 专题笔谈 • 上一篇    下一篇


杨婷婷, 高谦()   

  1. 200032 上海,复旦大学基础医学院
  • 收稿日期:2021-05-18 出版日期:2021-07-10 发布日期:2021-07-09
  • 通信作者: 高谦

The tuberculosis drug-resistance and transmission surveillance network based on whole genome sequencing data

YANG Ting-ting, GAO Qian()   

  1. School of Basic Medical Science, Fudan University, Shanghai 200032, China
  • Received:2021-05-18 Online:2021-07-10 Published:2021-07-09
  • Contact: GAO Qian


结核病耐药和传播监测能够为公共卫生决策提供重要信息。结核分枝杆菌全基因组测序(whole genome sequencing,WGS)分析在耐药检测和传播鉴定上比传统表型药物敏感性试验方法和基因分型方法具有更大优势,在发达国家已经应用。全基因组数据分析平台SAM-TB的建立使得构建基于结核分枝杆菌WGS的全国结核病耐药和传播监测数据库成为可能。笔者建议目前以省为单位,逐步推进这项工作,最终形成覆盖全国的结核病耐药和传播监测网络。

关键词: 分枝杆菌, 结核, 基因组, 细菌, 序列分析, DNA, 抗药性, 细菌, 人群监测


The surveillance of tuberculosis drug-resistance and transmission provide important information to making up public health policies. Whole genome sequencing (WGS) of Mycobacterium tuberculosis (MTB) has an advantage over the traditional phenotypic drug susceptibility test and genotyping in drug resistance detection and transmission identification, and has been introduced into the health system of some developed countries. The establishment of the WGS data analysis platform, SAM-TB, makes it possible to construct a national tuberculosis drug-resistance and transmission surveillance database base on MTB WGS data. The authors suggest that this work should be carried out step by step at the provincial level, and finally a nationwide surveillance network of tuberculosis drug resistance and transmission can be formed.

Key words: Mycobacterium tuberculosis, Genome, bacterial, Sequence analysis, DNA, Drug resistance, bacterial, Population surveillance