干细胞与结核分枝杆菌交互作用的研究进展

doi:10.3969/j.issn.1000-6621.2021.02.015

摘要/Abstract

摘要：

结核分枝杆菌是引起人类结核病的主要病原菌。作为胞内致病菌,结核分枝杆菌在宿主细胞内潜伏或增殖,其不仅能被宿主吞噬细胞所吞入,还可入侵以造血干细胞和间充质干细胞为代表的干细胞。由于干细胞具有自我复制、多能分化、高度迁移和免疫调节等特性,其在结核病发生和发展中的作用不可忽视。作者主要从结核分枝杆菌与干细胞之间的交互作用这一角度对结核病的发病机制和防治策略进行综述和展望。

关键词: 干细胞, 分枝杆菌,结核, 交互分析, 结核, 免疫调节

Abstract:

Tuberculosis is mainly caused by an intracellular pathogen—Mycobacterium tuberculosis, which can lurk or proliferate in host cells. It can also invade stem cells such as hematopoietic stem cells and mesenchymal stem cells. Stem cells are capable of self-replication, pluripotent differentiation, high migration and immune regulation, thus the role of them in the occurrence and development of tuberculosis can not be ignored. We mainly reviewed the pathogenesis and prevention and treatment strategies of tuberculosis through the interaction between Mycobacterium tuberculosis and stem cells.

Key words: Stem cells, Mycobacterium tuberculosis, Transactional analysis, Tuberculosis, Immunomodulation

郭倩, 申晨, 申阿东. 干细胞与结核分枝杆菌交互作用的研究进展[J]. 中国防痨杂志, 2021, 43(2): 186-189. doi: 10.3969/j.issn.1000-6621.2021.02.015

GUO Qian, SHEN Chen, SHEN A-dong. Research progress of stem cells in Mycobacterium tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2021, 43(2): 186-189. doi: 10.3969/j.issn.1000-6621.2021.02.015

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