巨噬细胞极化与结核分枝杆菌感染的研究进展

doi:10.19982/j.issn.1000-6621.20230265

摘要/Abstract

摘要：

结核病是由结核分枝杆菌(Mycobacterium tuberculosis,MTB)感染引起的慢性传染性疾病,严重危害人类健康,耐药MTB的出现加剧了疾病治疗的困难。作为抵抗MTB的主要宿主细胞,巨噬细胞极化的M1型和M2型巨噬细胞两个亚群在宿主结核感染中发挥了不同的作用。巨噬细胞的极化状态与结核病的发生、进展和转归密切相关,本文对结核病相关的M1型和M2型巨噬细胞之间极化的动态平衡及所涉及的信号通路进行综述,以期为结核病疫苗的研制和有效防治提供理论依据。

关键词: 分枝杆菌,结核, 极化, 巨噬细胞, 综述文献(主题)

Abstract:

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB), which seriously endangers human health, and the emergence of drug-resistant MTB greatly exacerbates the difficulty of treatments. As an essential factor against MTB, macrophage polarizes into two subpopulations including M1 and M2 types once infected, which exhibit distinguish impacts during host infection. Macrophage polarization is tightly related to the occurrence, progression, and prognosis of tuberculosis diseases. In this review, the authors summarized the dynamic balance of polarization between M1 and M2 macrophages and polarization-related pathways during MTB infection, which might provide some perspectives for vaccine development, prevention, and treatment of tuberculosis diseases.

Key words: Mycobacterium tuberculosis, Polarization, Macrophage, Review literature as topic

中图分类号:

R152
R183.3

吴显劲, 黄海勇, 萧乐瑶, 徐军发. 巨噬细胞极化与结核分枝杆菌感染的研究进展[J]. 中国防痨杂志, 2023, 45(12): 1198-1204. doi: 10.19982/j.issn.1000-6621.20230265

Wu Xianjin, Huang Haiyong, Xiao Leyao, Xu Junfa. Research progress on macrophage polarization and Mycobacterium tuberculosis infection[J]. Chinese Journal of Antituberculosis, 2023, 45(12): 1198-1204. doi: 10.19982/j.issn.1000-6621.20230265

图/表 1

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