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中国防痨杂志 ›› 2022, Vol. 44 ›› Issue (3): 294-298.doi: 10.19982/j.issn.1000-6621.20210646

• 综述 • 上一篇    下一篇

结核病分子生物学检测技术研究进展

樊茹1, 李晓非2()   

  1. 1大理大学公共卫生学院,大理 671003
    2昆明市第三人民医院云南省传染性疾病临床医学中心,昆明 650041
  • 收稿日期:2021-11-12 出版日期:2022-03-10 发布日期:2022-03-08
  • 通信作者: 李晓非 E-mail:1971069866@qq.com
  • 基金资助:
    云南省科技厅科技计划项目(202001BA070001-136)

Research progress of molecular biology detection technology for tuberculosis

FAN Ru1, LI Xiao-fei2()   

  1. 1School of Public Health, Dali University, Dali 671003, China
    2Yunnan Provincial Center for Infectious Diseases Clinical Medicine, Kunming Third People’s Hospital, Kunming 650041, China
  • Received:2021-11-12 Online:2022-03-10 Published:2022-03-08
  • Contact: LI Xiao-fei E-mail:1971069866@qq.com
  • Supported by:
    Science and Technology Planning Project of Yunnan Provincial Department of Science and Technology(202001BA070001-136)

摘要:

随着医学科学技术的不断发展,特别是精准诊疗时代的来临,分子生物学检测技术在结核病早期诊断辅助方面受到广泛重视和应用。分子生物学检测技术具有准确、高效、高通量等优点,为结核病的诊疗及疫情的防控带来了新曙光。本文中,笔者综合国内外学者研究成果,阐述了基于核酸扩增试验技术、核酸分子杂交技术、基因测序的结核病检测及药物敏感性分析技术和其他新型结核病检测技术的应用现状及其最新研究进展,以期为结核病的辅助诊断提供参考。

关键词: 分枝杆菌,结核, 分子诊断技术, 综述文献(主题)

Abstract:

With the continuous development of medical science and technology, especially the advent of the era of precise diagnosis and treatment, molecular biology detection technology has been widely valued and applied in the early diagnosis of tuberculosis. Molecular biological detection technology has the advantages of accuracy, high efficiency and high throughput, which brings a new dawn for the diagnosis and treatment of tuberculosis and the prevention and control of the epidemic. Researches at home and abroad were summarized to expound the application status and the latest research progress based on nucleic acid amplification test technology, gene sequencing tuberculosis detection and drug sensitivity analysis technology and other new tuberculosis detection technology, in order to provide reference for the auxiliary diagnosis of tuberculosis.

Key words: Mycobacterium tuberculosis, Molecular diagnostic techniques, Review literature as topic

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