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中国防痨杂志 ›› 2021, Vol. 43 ›› Issue (8): 843-846.doi: 10.3969/j.issn.1000-6621.2021.08.017

• 综述 • 上一篇    下一篇

Xpert MTB/RIF Ultra在儿童结核病诊断中的应用进展

王亚翠, 孙琳(), 申阿东()   

  1. 100045 国家儿童医学中心 首都医科大学附属北京儿童医院呼吸疾病研究室 北京市儿科研究所 儿科学国家重点学科 教育部儿科重大疾病研究重点实验室 儿童呼吸道感染性疾病研究北京市重点实验室
  • 收稿日期:2021-03-08 出版日期:2021-08-10 发布日期:2021-07-30
  • 通信作者: 孙琳,申阿东;
  • 基金资助:

Application progress of Xpert MTB/RIF Ultra assay in tuberculosis diagnosis in children

WANG Ya-cui, SUN Lin(), SHEN A-dong()   

  1. Key Laboratory of Major Diseases in Children and National Key Discipline of Pediatrics (Capital Medical University), Ministry of Education, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
  • Received:2021-03-08 Online:2021-08-10 Published:2021-07-30
  • Contact: SUN Lin,SHEN A-dong;


儿童结核病临床表现不典型,检测标本中结核分枝杆菌载量低,加之传统实验室检查方法敏感度低且耗时长,使得儿童结核病早期精准诊断面临巨大挑战。新一代Xpert MTB/RIF Ultra(简称“Xpert Ultra”)方法凭借其较高的检测性能和较短的检测时间,正逐渐引起研究者和临床医生的关注。笔者对Xpert Ultra技术在儿童结核病诊断中的应用进行综述,以期为儿童结核病诊治提供帮助。

关键词: 结核, 儿童, 诊断, 核酸扩增技术, 综述文献(主题)


Accurate diagnosis of tuberculosis timely is challenging in children because of the nonspecific clinical manifestations, low load of Mycobacterium tuberculosis in specimens, and insensitive and time-consuming characteristics of traditional diagnostic methods. Xpert MTB/RIF Ultra (Xpert Ultra), a new generation assay of Xpert, is gradually attract the attention of researchers and clinicians due to its superior performance and shorter turnaround time. In this review, the application of Xpert Ultra technology in pediatric tuberculosis was summarized to provide assistant for the diagnosis and treatment.

Key words: Tuberculosis, Child, Diagnosis, Nucleic acid amplification techniques, Review literature as topic